ID E9PWU1_MOUSE Unreviewed; 230 AA.
AC E9PWU1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Guanylyl cyclase-activating protein 2 {ECO:0000256|ARBA:ARBA00014954};
DE AltName: Full=Guanylate cyclase activator 1B {ECO:0000256|ARBA:ARBA00033142};
GN Name=Guca1b {ECO:0000313|Ensembl:ENSMUSP00000126799.2,
GN ECO:0000313|MGI:MGI:1194489};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000126799.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000126799.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000126799.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000126799.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000126799.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006523525.1; XM_006523462.2.
DR AlphaFoldDB; E9PWU1; -.
DR SMR; E9PWU1; -.
DR ProteomicsDB; 368111; -.
DR Antibodypedia; 30141; 156 antibodies from 22 providers.
DR DNASU; 107477; -.
DR Ensembl; ENSMUST00000145462.2; ENSMUSP00000126799.2; ENSMUSG00000023979.15.
DR AGR; MGI:1194489; -.
DR MGI; MGI:1194489; Guca1b.
DR VEuPathDB; HostDB:ENSMUSG00000023979; -.
DR GeneTree; ENSGT00940000157530; -.
DR HOGENOM; CLU_1204453_0_0_1; -.
DR OrthoDB; 339700at2759; -.
DR PhylomeDB; E9PWU1; -.
DR BioGRID-ORCS; 107477; 4 hits in 77 CRISPR screens.
DR ChiTaRS; Guca1b; mouse.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000023979; Expressed in layer of retina and 51 other cell types or tissues.
DR ExpressionAtlas; E9PWU1; baseline and differential.
DR GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028846; Recoverin.
DR PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1.
DR PANTHER; PTHR23055:SF11; GUANYLYL CYCLASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT DOMAIN 53..88
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 89..124
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 230 AA; 26217 MW; 32B9A2971CDEDA34 CRC64;
MGQQLSWEEA EAAGEMDVAE LQEWYKKFVV ECPSGTLFMH EFKRFFKVTG NEEASQYVES
MFRAFDKNGD NTIDFLEYVA ALNLVLRGSL EHKLKWTFKI YDKDRNGCID RLELLDIVEA
IYKLKKACRA ELDLEHQGQL LTPEEVVDRI FLLVDENGDG KRDAVCRETA LSVRYASQKS
PTPTTTSLLL IHMSVNRLEK DGMNSKGAKT QAHTFVRALP RLAGEGWASK
//
