ID E9Q020_MOUSE Unreviewed; 495 AA.
AC E9Q020;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=WW domain containing adaptor with coiled-coil {ECO:0000313|Ensembl:ENSMUSP00000127848.2};
GN Name=Wac {ECO:0000313|Ensembl:ENSMUSP00000127848.2,
GN ECO:0000313|MGI:MGI:2387357};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000127848.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000127848.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127848.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000127848.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127848.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; E9Q020; -.
DR SMR; E9Q020; -.
DR jPOST; E9Q020; -.
DR MaxQB; E9Q020; -.
DR PeptideAtlas; E9Q020; -.
DR ProteomicsDB; 324441; -.
DR Antibodypedia; 50013; 147 antibodies from 26 providers.
DR Ensembl; ENSMUST00000171486.8; ENSMUSP00000127848.2; ENSMUSG00000024283.16.
DR AGR; MGI:2387357; -.
DR MGI; MGI:2387357; Wac.
DR VEuPathDB; HostDB:ENSMUSG00000024283; -.
DR GeneTree; ENSGT00440000037780; -.
DR ChiTaRS; Wac; mouse.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000024283; Expressed in undifferentiated genital tubercle and 257 other cell types or tissues.
DR ExpressionAtlas; E9Q020; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR InterPro; IPR038867; WAC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR15911; WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL; 1.
DR PANTHER; PTHR15911:SF6; WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:E9Q020,
KW ECO:0007829|MaxQB:E9Q020};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 90..117
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 53952 MW; A48906EEB9040F73 CRC64;
MRDAADPSPP NKMLRRSNSP ENKYSDSTGH NKAKNVHTQR VRERDGGTSY SPQENSHNHS
ALHSSNSHSS NPSNNPSKTS DAPYDSADDW SEHISSSGKK YYYNCRTEVS QWEKPKEWLE
REQRQKEANK LAVNSFPKDR DYRREVMQAT ATSGFTSGKS APGDKSISHS CTTPSTSSAS
GLNPTSAPPT SASAVPVSPV PQSTIPPLLQ DPNLFRQLLP ALQATLQLNN SNVDISKINE
AAVTQASLQS IIHKFLTAGP SAFNITSLIS QAAQLSTQAQ PSNQSPMSLT SDASSPRSYV
SPRISTPQTN TVPMKPLIST PPVSSQPKVS TPVVKQGPVS HSATQQPVTA DKQQSHDPVS
PRSLQRLSSQ RSPSPGPNHT CSSNASTATV VPQNASARPA CSLTPTLAAH FNDNLIKHVQ
GWPADHAEKQ ASRLREEAHN MGSVHMSEIC TELKNLRSLV RVCEIQATLR EQRILFLRQQ
IKELEKLKNQ NSFMV
//
