ID E9Q2X6_MOUSE Unreviewed; 1261 AA.
AC E9Q2X6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN Name=Smc4 {ECO:0000313|Ensembl:ENSMUSP00000103433.2,
GN ECO:0000313|MGI:MGI:1917349};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000103433.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000103433.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103433.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000103433.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103433.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
CC {ECO:0000256|ARBA:ARBA00006005}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; E9Q2X6; -.
DR SMR; E9Q2X6; -.
DR jPOST; E9Q2X6; -.
DR MaxQB; E9Q2X6; -.
DR PeptideAtlas; E9Q2X6; -.
DR ProteomicsDB; 324371; -.
DR Antibodypedia; 18504; 281 antibodies from 35 providers.
DR Ensembl; ENSMUST00000107803.7; ENSMUSP00000103433.2; ENSMUSG00000034349.15.
DR AGR; MGI:1917349; -.
DR MGI; MGI:1917349; Smc4.
DR VEuPathDB; HostDB:ENSMUSG00000034349; -.
DR GeneTree; ENSGT00900000141094; -.
DR HOGENOM; CLU_001042_4_1_1; -.
DR ChiTaRS; Smc4; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000034349; Expressed in late embryo and 283 other cell types or tissues.
DR ExpressionAtlas; E9Q2X6; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProt.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF172; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 1: Evidence at protein level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Proteomics identification {ECO:0007829|EPD:E9Q2X6,
KW ECO:0007829|MaxQB:E9Q2X6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 586..701
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..485
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 514..548
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 749..776
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 865..983
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1261 AA; 144207 MW; 4FCA6E17A573852B CRC64;
MRRKGTKPST ACHQEEGPPP SQDGAHSDEE MEQPAGEAES AAPATMASEA GAPRLMITHI
VNQNFKSYAG EKVLGPFHKR FSCIIGPNGS GKSNVIDSML FVFGYRAQKI RSKKLSVLIH
NSDEHKDIQS CTVEVHFQKI IDKEGDDYEV LPNSNFYVSR TAYRDSTSVY HISGKKKTFK
DVGNLLRSHG IDLDHNRFLI LQGEVEQIAM MKPKGQTEHD EGMLEYLEDI IGCGRLNEPI
KVLCRRVEIL NEHRGEKLNR VKMVEKEKDA LEGEKNIAIE FLTLENEMFK KKNHICQYYI
YDLQNRIAEI TTQKEKIHED TKEITEKSNV LSNEMKAKNS AVKDVEKKLN KVTKFIEQNK
EKFTQLDLED VQVREKLKHA TSKAKKLEKQ LQKDKEKVEE LKSVPAKSKT VINETTTRNN
SLEKEREKEE KKLKEVMDSL KQETQGLQKE KEIQEKELMG FNKSVNEARS KMEVAQSELD
IYLSRHNTAV SQLSKAKEAL ITASETLKER KAAIKDINTK LPQTQQELKE KEKELQKLTQ
EEINLKSLVH DLFQKVEEAK SSLAMNRSRG KVLDAIIQEK KSGRIPGIYG RLGDLGAIDE
KYDIAISSCC HALDYIVVDS IDTAQECVNF LKKHNIGIAT FIGLDKMTVW AKKMSKIQTP
ENTPRLFDLV KVKNEEIRQA FYFALRDTLV ANNLDQATRV AYQRDRRWRV VTLQGQIIEQ
SGTMSGGGSK VMRGRMGSSV IDEISVEEVN KMESQLERHS KQAMQIQEQK VQHEEAVVKL
RHSERDMRNT LEKFAASIQG LSEQEEYLCV QIKELEANVL TTAPDRKQQK LLEENVSVFK
KEYDAVAEKA GKVEAEIKRL HNTIIDINNR KLKAQQNKLD TINKQLDECA SAITKAQVAI
KTADRNLKKA QDSVCRTEKE IKDTEKEIND LKTELKNIED KAEEVINNTK TAETSLPEIQ
KEHRNLLQEL KVIQENEHAL QKDALSIKLK LEQIDGHISE HNSKIKYWQK EISKIKLHPV
EDNPVETVAV LSQEELEAIK NPESITNEIA LLEAQCREMK PNLGAIAEYK KKEDLYLQRV
AELDKITSER DNFRQAYEDL RKQRLNEFMA GFYVITNKLK ENYQMLTLGG DAELELVDSL
DPFSEGIMFS VRPPKKSWKK IFNLSGGEKT LSSLALVFAL HHYKPTPLYF MDEIDAALDF
KNVSIVAFYI YEQTKNAQFI IISLRNNMFE ISDRLIGIYK TYNSTKSVAV NPKQIASKGL
C
//
