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Database: UniProt
Entry: E9QI09_DANRE
LinkDB: E9QI09_DANRE
Original site: E9QI09_DANRE 
ID   E9QI09_DANRE            Unreviewed;      1038 AA.
AC   E9QI09;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   25-OCT-2017, entry version 46.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 5a {ECO:0000313|Ensembl:ENSDARP00000040501};
GN   Name=trpc5a {ECO:0000313|Ensembl:ENSDARP00000040501,
GN   ECO:0000313|ZFIN:ZDB-GENE-040812-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000040501, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000040501}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000040501};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000040501, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000040501,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000040501}.
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DR   EMBL; AL953910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000040502; ENSDARP00000040501; ENSDARG00000070504.
DR   ZFIN; ZDB-GENE-040812-1; trpc5a.
DR   GeneTree; ENSGT00760000119180; -.
DR   Reactome; R-DRE-3295583; TRP channels.
DR   Proteomes; UP000000437; Chromosome 1.
DR   Bgee; ENSDARG00000070504; -.
DR   ExpressionAtlas; E9QI09; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005461; TRPC5_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    331    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    417       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    437    456       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    476    497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    599    621       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT       69     95       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN       69     95       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
SQ   SEQUENCE   1038 AA;  117239 MW;  D2EBDD7E16E2ADB6 CRC64;
     MSHLYYKKSS YSPYRDRIPL QIVRAEVELS PEERAFLSAV EKGDYAGVQH ALREAEVYYN
     IDTNCVDPLG RSALLIAIEN ENLEVMELLL DHGVNTGDAL LYAIRKEVVG AVELLLSHRK
     PSGEKQVPSL MMDAQFSEFT PDITPIMLAA HTNNYEIIKL LVQRKVTIPR PHQIRCDCVE
     CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFRQE
     YEELSQQCKL FAKDLLDQAR SSRELETILN HRDDQSEELD PRECRDLAKL KLAIKYHQKE
     FVAQPNCQQL LATLWYDGFP GWRRRHWAVK LVMCFIIGLL FPVFSLVYLL APKSTLGLFI
     KKPFIKFICH TASYLTFLFL LLLASQHIAR TNLHMQGPPP TVVEWMILPW VLGFIWAEIK
     EMWDGGFNEY VHDWWNLMDF AMNSLYLATI SLKIVAYVKY NSSRPREEWE MWHPTLIAEA
     LFAIANIFSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
     YYETEAADEP NHCKGIRCER QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
     GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGGTLPPP
     FNIIPSPKSF WYLCRWVHGR LCGSETAPPE EDTHKHENLK EFTEKHADRL IQNQHYQEVI
     RSLVKRYVAS MIRSAKTSEG LTEENFKELK QDISSFRYEV LDLLGNRKPP RRNYSSSSEA
     TLRDEVSDDG EARHHSDGSS IGAKGVSFKT ITPSDPSYGV SALFHSISGM EAAGTTREGK
     PKINGLRKNP SPSSSLSSVA PARAPALSRT WRRFSRFSSS KKNSFRRLGL LFSRMGSHLP
     QPTGVTAATY TISDGLLHPP GAWHDLGFTR GDGPVTRSET NLNQVATLNE GGIGIGGSGV
     GMSTNGQRAN GRDVLLTLGP LSPPSSLHCA SSFSASSSRL LDSNEDVFQG LVGPCVGQMP
     HSSSCWVTEQ DDSVTTQL
//
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