ID E9QLB2_MOUSE Unreviewed; 239 AA.
AC E9QLB2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=palmitoyl-protein hydrolase {ECO:0000256|ARBA:ARBA00012423};
DE EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
GN Name=Lyplal1 {ECO:0000313|Ensembl:ENSMUSP00000048229.8,
GN ECO:0000313|MGI:MGI:2385115};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000048229.8, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000048229.8, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000048229.8,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000048229.8}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000048229.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC family. {ECO:0000256|ARBA:ARBA00006499}.
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DR RefSeq; NP_666218.2; NM_146106.2.
DR AlphaFoldDB; E9QLB2; -.
DR SMR; E9QLB2; -.
DR IntAct; E9QLB2; 13.
DR SwissPalm; E9QLB2; -.
DR jPOST; E9QLB2; -.
DR MaxQB; E9QLB2; -.
DR PeptideAtlas; E9QLB2; -.
DR ProteomicsDB; 361799; -.
DR Antibodypedia; 34624; 190 antibodies from 28 providers.
DR DNASU; 226791; -.
DR Ensembl; ENSMUST00000045388.8; ENSMUSP00000048229.8; ENSMUSG00000039246.9.
DR GeneID; 226791; -.
DR KEGG; mmu:226791; -.
DR UCSC; uc007dzm.2; mouse.
DR AGR; MGI:2385115; -.
DR CTD; 127018; -.
DR MGI; MGI:2385115; Lyplal1.
DR VEuPathDB; HostDB:ENSMUSG00000039246; -.
DR GeneTree; ENSGT00940000159171; -.
DR HOGENOM; CLU_049413_3_6_1; -.
DR OMA; LEYPHIK; -.
DR OrthoDB; 4670340at2759; -.
DR PhylomeDB; E9QLB2; -.
DR TreeFam; TF314619; -.
DR BioGRID-ORCS; 226791; 1 hit in 79 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000039246; Expressed in right kidney and 220 other cell types or tissues.
DR Genevisible; E9QLB2; MM.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:Ensembl.
DR GO; GO:0160049; P:negative regulation of cGAS/STING signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003140; PLipase/COase/thioEstase.
DR PANTHER; PTHR10655:SF71; LYSOPHOSPHOLIPASE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR10655; LYSOPHOSPHOLIPASE-RELATED; 1.
DR Pfam; PF02230; Abhydrolase_2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:E9QLB2,
KW ECO:0007829|PeptideAtlas:E9QLB2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 14..226
FT /note="Phospholipase/carboxylesterase/thioesterase"
FT /evidence="ECO:0000259|Pfam:PF02230"
SQ SEQUENCE 239 AA; 26340 MW; 3CAEB24CB252D42D CRC64;
MAAVPSAVHL PRCVVSPTGR HSASLIFLHG SGHSGQGQRE WIKHVLNQDL TFQHIKIIYP
TAPSRPYTPL KGGLSNVWFD RFKISMDCPE HLESIDSMCQ VLSGLVDEEV KTGIQKSRIL
IGGFSMGGCM AMHLAYRSHP DVAGVFVLSG FLNKASVVYQ DLQQGGRMLP ELFQCHGSAD
NLVLHAWGKE TNSKLKSLGV STTFHSLPNL NHELNKTELE KLKSWILTRL PGETDGQSE
//