ID E9QP76_MOUSE Unreviewed; 602 AA.
AC E9QP76;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Rhotekin 2 {ECO:0000313|Ensembl:ENSMUSP00000101077.2};
GN Name=Rtkn2 {ECO:0000313|Ensembl:ENSMUSP00000101077.2,
GN ECO:0000313|MGI:MGI:2158417};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101077.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000101077.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101077.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000101077.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101077.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001074815.1; NM_001081346.1.
DR AlphaFoldDB; E9QP76; -.
DR SMR; E9QP76; -.
DR MaxQB; E9QP76; -.
DR ProteomicsDB; 322139; -.
DR Antibodypedia; 28261; 152 antibodies from 25 providers.
DR Ensembl; ENSMUST00000105437.8; ENSMUSP00000101077.2; ENSMUSG00000037846.19.
DR UCSC; uc007fmd.1; mouse.
DR AGR; MGI:2158417; -.
DR MGI; MGI:2158417; Rtkn2.
DR VEuPathDB; HostDB:ENSMUSG00000037846; -.
DR GeneTree; ENSGT00940000157470; -.
DR BioGRID-ORCS; 170799; 2 hits in 78 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000037846; Expressed in right lung lobe and 117 other cell types or tissues.
DR ExpressionAtlas; E9QP76; baseline and differential.
DR Genevisible; E9QP76; MM.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13249; PH_rhotekin2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR012966; AHD.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21538; ANILLIN/RHOTEKIN RTKN; 1.
DR PANTHER; PTHR21538:SF21; RHOTEKIN-2; 1.
DR Pfam; PF08174; Anillin; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51860; REM_1; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207};
KW Proteomics identification {ECO:0007829|MaxQB:E9QP76,
KW ECO:0007829|PeptideAtlas:E9QP76};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..74
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 279..385
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 479..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66750 MW; BF799028421A6970 CRC64;
MEGQLLRGLA AQQDCSIREK IDLEIRMREG IWKLLSLSTK KDQVLHAVKN LMVCSARIQA
YTAELQKSKE EIANQTGARD SSSENKEGES CRGKIALSDI RIPLMWKDSD HFSNKECTQR
FAIFCLFRMG AQVFDTDMVI VDQTVTDICF ENVTIFNEAG PDFQIKIEVY SCSAEESSLT
NTPRKLAKKL KTSISKATGR KISAALQEES PEACLLAGSA VLGAKYHLLA HTTLTLENAG
DCFKTHNLSV HGDEECSFWL PLYGNVCCRL VAQPACMAAD AFAGFLNEQQ TGKGLVGWRR
LYCALRGGKL RCFYGPEEIE AKVEPALVVP IDKETRIQAV EKDSKKMHCF SVLSTAAGRA
VSHIFAADSL ADFQEWMGAF RQHFFDLSQW KHCCEELMRI EIMSPRKPPL FLAKEATSVY
YDMSIDSPVK LESVTDIIQK KIGETNRQFL IGRDDQSAAP PWAAVFDGNH EMVIEKKVLS
PIGEPAPDGK RKKRRAPLPP TDQPPFCIKT QGRANQSKDS ATQAGVSGAS SSPSDPRLSP
PTHHLQKPVA APRKLLPARK NSSADIGHTD TKTSLDAKPV PVPRQKSIRD ILDPRSWLQA
QV
//