ID E9QPI2_MOUSE Unreviewed; 705 AA.
AC E9QPI2; E9QL78;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=NOL1/NOP2/Sun domain family, member 7 {ECO:0000313|Ensembl:ENSMUSP00000031109.5};
GN Name=Nsun7 {ECO:0000313|Ensembl:ENSMUSP00000031109.5,
GN ECO:0000313|MGI:MGI:1918168};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000031109.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000031109.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000031109.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000031109.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000031109.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR RefSeq; NP_001289762.1; NM_001302833.1.
DR AlphaFoldDB; E9QPI2; -.
DR SMR; E9QPI2; -.
DR ProteomicsDB; 370124; -.
DR Antibodypedia; 11775; 43 antibodies from 13 providers.
DR DNASU; 70918; -.
DR Ensembl; ENSMUST00000031109.7; ENSMUSP00000031109.5; ENSMUSG00000029206.14.
DR GeneID; 70918; -.
DR KEGG; mmu:70918; -.
DR UCSC; uc008xou.2; mouse.
DR UCSC; uc057aab.1; mouse.
DR AGR; MGI:1918168; -.
DR CTD; 79730; -.
DR MGI; MGI:1918168; Nsun7.
DR VEuPathDB; HostDB:ENSMUSG00000029206; -.
DR GeneTree; ENSGT00940000157352; -.
DR OrthoDB; 5312486at2759; -.
DR PhylomeDB; E9QPI2; -.
DR BioGRID-ORCS; 70918; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Nsun7; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000029206; Expressed in ventricular system choroidal fissure and 79 other cell types or tissues.
DR ExpressionAtlas; E9QPI2; baseline and differential.
DR Genevisible; E9QPI2; MM.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR049561; NSUN5_7_fdxn-like.
DR InterPro; IPR042620; NSUN7.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14663:SF2; METHYLTRANSFERASE NSUN7-RELATED; 1.
DR PANTHER; PTHR14663; UNCHARACTERIZED; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF21148; NSUN5_fdxn-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW Proteomics identification {ECO:0007829|ProteomicsDB:E9QPI2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 200..514
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 543..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 445
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 705 AA; 79799 MW; 4148B1AC2952D486 CRC64;
MLDPTSERDL FDQENMEEIS QLASLEMSGD VVANTNSSTV VLEKPSYPDS VYVTAANIFQ
GIRIQRSPDK VIINYGSEPL QPSSSRSEDE SFQRLSYELA FSTLKYQDIL ESILIDSYIF
SSTTIASQLN SLIIVMLYDF QDRKFQPRIL SENEETIPEV QEVENLLNGF KTKLAAALAR
CRIKHDALSI YHILPETVRK QEQRASTLPL YAWINTSKIS LEEVYNNLRR KGYSKVKSIT
SVNEKVYAVD QHCFNVLIFP AHLKTDLLNI DLIKDYKLIF QDKSRSLAVH SVKALINIDD
DVLMVNTGSW YTVAHMSILT SGHTSKIFVC GIQQEEKDFN ARKLFTRMGC QNIEILHETF
LSIESKDHRL QNVKVILLLP RCSSLGVSNP VEFILNEHED KSLLQDLSQG GLPKDKLETL
VQQQFEQLTH AMKFTKVQAI VYCTCSVSKE ENEDVVEKAL EYQSSGVKMQ PYRLSPPVLP
LCTLKEIELS MDRFFRLEPS DMNNGCFLSI LTRERDPSET VSVKDVLARA AAKGLLEGVE
VGKTLKRDKK RKKSKALPSR APHHGDPLRD HLAVDGNDTS NVQMKISELL HRESKISTST
KMSAPAKTVS QAGTSSQVRK PSKPLSTPLV RNFSRPVERP TNFVRARPEG KVIPLKPIEI
VLPPVIFPLS SQGPRVQMPA THFYYRFIGS KDSSREDRIN NFLIK
//
