ID   E9RU69_9FIRM            Unreviewed;       698 AA.
AC   E9RU69;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN   ORFNames=HMPREF0490_01000 {ECO:0000313|EMBL:EGC75383.1};
OS   Lachnospiraceae bacterium 6_1_37FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658656 {ECO:0000313|EMBL:EGC75383.1, ECO:0000313|Proteomes:UP000006471};
RN   [1] {ECO:0000313|EMBL:EGC75383.1, ECO:0000313|Proteomes:UP000006471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6_1_37FAA {ECO:0000313|EMBL:EGC75383.1,
RC   ECO:0000313|Proteomes:UP000006471};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA   Yandava C., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 6_1_37FAA.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGC75383.1}.
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DR   EMBL; ADCR01000008; EGC75383.1; -; Genomic_DNA.
DR   AlphaFoldDB; E9RU69; -.
DR   STRING; 658656.HMPREF0490_01000; -.
DR   HOGENOM; CLU_007352_0_0_9; -.
DR   Proteomes; UP000006471; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        177..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        525..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        549..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        575..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        616..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        654..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..333
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          405..676
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   698 AA;  77341 MW;  C367023A498AC01C CRC64;
     MIRVVKVGKW IAKHRIFILL VSILLLIPAA IGKAETKINY DLLSYLPGDL ETVKGQDILV
     DEYGMGAFSM VVVEGMELKD VQKLEEKFSE VDHVKDVMWY DDVADISLPV EMIPKDLRKA
     FFNGDATMML ALFDNTTSSD EAMEAVTNMR KIADKQCFIS GMTGIVTDIK NISLQELPIY
     VVIATLLSFF VLELTGTSFL VPIFFLISIG AAVLYNLGSN IFLGEISYIT EALTAVLQLG
     VTMDYSIFLL NSYEENKLRF PGEKERAMGH AIANTFKSVV GSSVTTVAGF MALCFMTFAL
     GKDLGIVMAK GVVIGVLCCV TLLPSLILIF DKAIEKTKHR PLIKSIDKPS AFITKHYRLW
     LILFAVLLFP AIYGNNHTKI YYNIAQSLPD TLPANVANKK LVDDFKMSNM HMILMQKDMD
     AKDKRKMLEE IDEVDGVKWS LGMNTLFGPT IPESMIPDDM KKMLQSDNYE LAFICSEYES
     ATDEVNKQIS EIDKIVKSYS KHAMVIGEAP LMKDLQDTTD VDLKTVNAIS ILAIFIIIMI
     VFKSISLPVI LVAVIEFAIF VNMAIPYYQG TSLPFVASIV IGTIQLGATV DYAILMTSRY
     QKERGKGKDK KTAISIAHRA SMLSIISSGF SFFAATFGVA LYSKVDMIGS ICTLLARGAL
     ISMFVVILIL PAMFMIFDKV ICKTSAGFLG KKTAERSN
//