ID   E9RZF9_9FIRM            Unreviewed;       313 AA.
AC   E9RZF9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Transketolase-like pyrimidine-binding domain-containing protein {ECO:0000259|SMART:SM00861};
GN   ORFNames=HMPREF0490_02809 {ECO:0000313|EMBL:EGC73390.1};
OS   Lachnospiraceae bacterium 6_1_37FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658656 {ECO:0000313|EMBL:EGC73390.1, ECO:0000313|Proteomes:UP000006471};
RN   [1] {ECO:0000313|EMBL:EGC73390.1, ECO:0000313|Proteomes:UP000006471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6_1_37FAA {ECO:0000313|EMBL:EGC73390.1,
RC   ECO:0000313|Proteomes:UP000006471};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA   Yandava C., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 6_1_37FAA.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGC73390.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADCR01000027; EGC73390.1; -; Genomic_DNA.
DR   RefSeq; WP_008977551.1; NZ_JAQFAJ010000010.1.
DR   AlphaFoldDB; E9RZF9; -.
DR   STRING; 658656.HMPREF0490_02809; -.
DR   GeneID; 83603729; -.
DR   HOGENOM; CLU_009227_1_1_9; -.
DR   Proteomes; UP000006471; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR43825; PYRUVATE DEHYDROGENASE E1 COMPONENT; 1.
DR   PANTHER; PTHR43825:SF1; TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
FT   DOMAIN          7..172
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   313 AA;  33368 MW;  2AC68BDB4212D76F CRC64;
     MSDVKRIATR ESYGKALVEL GKLHENLVVL DADLAGATKT AMFQKEFPER HIDCGIAEGN
     MIGVAAGLAT TGKVPFASSF AMFAAGRAFE QVRNSVGYPK LNVKIGATHA GISVGEDGAT
     HQCNEDIALM RTIPGMVVIN PSDDVEAKAA VKAAYEHEGP VYLRFGRLAV PVINDNPEYK
     FELGKGIVLR EGTDVTIIAT GLEVSESLEA AKKLEADGIS AKVINIHTIK PLDEKLVIES
     AKETGKVVTV EEHSVIGGLG SAVCDVLSEN YPVKVLKIGV NDVFGESGPA LELIKKYELD
     ADSIYKKVKA FVS
//