ID E9RZP5_9FIRM Unreviewed; 701 AA.
AC E9RZP5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=4Fe-4S Mo/W bis-MGD-type domain-containing protein {ECO:0000259|PROSITE:PS51669};
GN ORFNames=HMPREF0490_02933 {ECO:0000313|EMBL:EGC73358.1};
OS Lachnospiraceae bacterium 6_1_37FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658656 {ECO:0000313|EMBL:EGC73358.1, ECO:0000313|Proteomes:UP000006471};
RN [1] {ECO:0000313|EMBL:EGC73358.1, ECO:0000313|Proteomes:UP000006471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6_1_37FAA {ECO:0000313|EMBL:EGC73358.1,
RC ECO:0000313|Proteomes:UP000006471};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA Yandava C., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 6_1_37FAA.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC73358.1}.
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DR EMBL; ADCR01000028; EGC73358.1; -; Genomic_DNA.
DR AlphaFoldDB; E9RZP5; -.
DR STRING; 658656.HMPREF0490_02933; -.
DR HOGENOM; CLU_000422_13_3_9; -.
DR Proteomes; UP000006471; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR PANTHER; PTHR43742; TRIMETHYLAMINE-N-OXIDE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 9..65
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 701 AA; 78445 MW; DA5B2897C4595E8C CRC64;
MSQKEHGKKQ VKKAVCGICA SGCPMDIYVE DGKIISVEGS KDLPGQSGGL CAKGAAARQY
IYNQERLLYP MKQVGEKGHG KFVRISWEEA YQTIAEKLLS IREQYGARST IFYAGYPKWY
RPALLHLANA YGSPNYCTES STCFQASNMA WKSIYGNDIC FPDLANANTV MLWASNLYHS
NTPMSKSYRG MKARGVKIIV VDPRNTVTAR EADIHLRLLP GTDGALALGM AQVMIEEDLY
DHEFVEKYVH GFEEYRAYVK QFTPEYTEKI TGVPAEKILE AARLYATNGP AGIMFSAATV
VHHINGVQNY RAVHTLVGLS GNYDRKGGHL ARPPVSAPVN EFGKVKRYDG EEAIGQKDFP
AWFALPCEEA QCTRLAEYIL KEEPYPLKAL VAFGMNHRMW PKPSYLQEAL KKLEFYVNVD
LFLSDSSDMA DIVLPAATFF EREEIRTMRG GMVGLSEAAV CPCGEAKNDI EIIQELARRM
GLSEPVFSGT YEEYMNYILK PTGLSVEELR GHQGGVQAKH LVFGTERSYE REGFATPTGK
AEFVSTVLEK YKDAYGYDGL PVYRDFREVS EVDRTVYPWI LNTGSRKPQY FHARVNRLPW
LAALEPATLV EMHPSDMESL QIQEGDRVIV TSPGGSMEGI AAAVRNNLPG MVHIYHGNKK
GEANELIPLT YLDPISGFPG YKSYFCNVRR KEEEDAISTE I
//
