ID EFGL_THEMA Reviewed; 683 AA.
AC Q9X1Y4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE RecName: Full=Elongation factor G-like protein;
GN OrderedLocusNames=TM_1651;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-G/EF-2
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
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DR EMBL; AE000512; AAD36718.1; -; Genomic_DNA.
DR PIR; H72227; H72227.
DR RefSeq; NP_229451.1; NC_000853.1.
DR RefSeq; WP_004082156.1; NZ_CP011107.1.
DR AlphaFoldDB; Q9X1Y4; -.
DR SMR; Q9X1Y4; -.
DR STRING; 243274.TM_1651; -.
DR PaxDb; 243274-THEMA_05990; -.
DR EnsemblBacteria; AAD36718; AAD36718; TM_1651.
DR KEGG; tma:TM1651; -.
DR eggNOG; COG0480; Bacteria.
DR InParanoid; Q9X1Y4; -.
DR OrthoDB; 9804431at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0032790; P:ribosome disassembly; IBA:GO_Central.
DR CDD; cd04170; EF-G_bact; 1.
DR CDD; cd16262; EFG_III; 1.
DR CDD; cd01434; EFG_mtEFG1_IV; 1.
DR CDD; cd03713; EFG_mtEFG_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR009022; EFG_III.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR047872; EFG_IV.
DR InterPro; IPR035649; EFG_V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004540; Transl_elong_EFG/EF2.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00484; EF-G; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..683
FT /note="Elongation factor G-like protein"
FT /id="PRO_0000091278"
FT DOMAIN 5..267
FT /note="tr-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT BINDING 14..21
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 73..77
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 127..130
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 683 AA; 75903 MW; E9408FF5A2C6A63C CRC64;
MGGLQNVRSA ALIGHNGSGK SLLLAQILYK SGLIDKADTK YVDYDPVEEE KGASFSSHVA
SLEWKGKKVY LIDTPGFSDF ISEVINGIFV SENIISVVNA VAGVEIQTER TWNMADEMKK
PIIVFVNQMD KERANFENVV AELKERFSRK IVPVVVPIGA AENFEGVVDL LKKKAYRYDG
DKVQEEDMPE SFNDMRSEIL EDIVEQDEEL MMRYLDGEDI GYDELMRVLK EGYKKGEIVP
VLSGSALKGI GLDLLLDYLG DIGVSPEEAP SYKALLEDGT EIEVKFSEEE PFCAYIFKSV
VDQFVGRITF AKVIAGVLRP GDTVVNVQKD VTEKVGHVYV PILKQQKEVE SAGPGEIVVL
LKLKEGAVGE TLAHRDRRVK IVPPAFPEPM FSRSVHPKSK SDIDKISSGL SRLSDSDPTF
VWEYDPETGE TVVSGLGAMH LDVMIERLKK IFGVDVEVGK PKIAYRETIT TTAVAEHKHK
KQTGGHGQYG HVKIQLEPLP RGQGYEFVDK IVGGVIPRNF IPSVDKGIRE AMKKGVLAGY
PVTDVRVILF DGSYHEVDSS DISFQIAAIQ AFKKGMEAAK PVILEPIMEV EVFVPEENAG
DVMGEISSRR GRPLGMEPSG KGMVKVKAEV PLAEMLDFSS KLSSITSGRG YFTMRFQRYE
IVPPNIQEKI IEERRREMQE QEK
//
