ID EHF_BOVIN Reviewed; 300 AA.
AC Q32LN0;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 01-MAY-2013, entry version 71.
DE RecName: Full=ETS homologous factor;
DE AltName: Full=ETS domain-containing transcription factor;
GN Name=EHF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional activator that may play a role in
CC regulating epithelial cell differentiation and proliferation. May
CC act as a repressor for a specific subset of ETS/AP-1-responsive
CC genes, and as a modulator of the nuclear response to mitogen-
CC activated protein kinase signaling cascades. Binds to DNA
CC sequences containing the consensus nucleotide core sequence GGAA.
CC Involved in regulation of TNFRSF10B/DR5 expression through Ets-
CC binding sequences on the TNFRSF10B/DR5 promoter (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- DOMAIN: The PNT domain acts as a transcriptional activator (By
CC similarity).
CC -!- SIMILARITY: Belongs to the ETS family.
CC -!- SIMILARITY: Contains 1 ETS DNA-binding domain.
CC -!- SIMILARITY: Contains 1 PNT (pointed) domain.
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DR EMBL; BC109503; AAI09504.1; -; mRNA.
DR IPI; IPI00690472; -.
DR RefSeq; NP_001033125.1; NM_001038036.2.
DR UniGene; Bt.101231; -.
DR ProteinModelPortal; Q32LN0; -.
DR SMR; Q32LN0; 208-299.
DR PRIDE; Q32LN0; -.
DR Ensembl; ENSBTAT00000022792; ENSBTAP00000022792; ENSBTAG00000017150.
DR GeneID; 505422; -.
DR KEGG; bta:505422; -.
DR CTD; 26298; -.
DR eggNOG; NOG307806; -.
DR GeneTree; ENSGT00700000104115; -.
DR HOGENOM; HOG000232188; -.
DR HOVERGEN; HBG074143; -.
DR InParanoid; Q32LN0; -.
DR KO; K09429; -.
DR OMA; NQLDANC; -.
DR OrthoDB; EOG4Z8XWV; -.
DR NextBio; 20867133; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Compara.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM_homology; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; FALSE_NEG.
DR PROSITE; PS00346; ETS_DOMAIN_2; FALSE_NEG.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1 300 ETS homologous factor.
FT /FTId=PRO_0000287132.
FT DOMAIN 29 115 PNT.
FT DNA_BIND 207 289 ETS.
SQ SEQUENCE 300 AA; 35004 MW; F20E8A1F0184DB86 CRC64;
MILEGSGVMN LNPSNNLLHQ QPTWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ
HLLDTNQLDA SCIPFQEFDV NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD
LFQSTHNVIV KTEQTDPSIM NTWKEENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTGHLP
IAESPDTKKE QDHPTKPHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGIFRFL
KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
//
