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Database: UniProt
Entry: EHF_BOVIN
LinkDB: EHF_BOVIN
Original site: EHF_BOVIN 
ID   EHF_BOVIN               Reviewed;         300 AA.
AC   Q32LN0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   14-MAY-2014, entry version 81.
DE   RecName: Full=ETS homologous factor;
DE   AltName: Full=ETS domain-containing transcription factor;
GN   Name=EHF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that may play a role in
CC       regulating epithelial cell differentiation and proliferation. May
CC       act as a repressor for a specific subset of ETS/AP-1-responsive
CC       genes, and as a modulator of the nuclear response to mitogen-
CC       activated protein kinase signaling cascades. Binds to DNA
CC       sequences containing the consensus nucleotide core sequence GGAA.
CC       Involved in regulation of TNFRSF10B/DR5 expression through Ets-
CC       binding sequences on the TNFRSF10B/DR5 promoter (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- DOMAIN: The PNT domain acts as a transcriptional activator (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the ETS family.
CC   -!- SIMILARITY: Contains 1 ETS DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 PNT (pointed) domain.
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DR   EMBL; BC109503; AAI09504.1; -; mRNA.
DR   RefSeq; NP_001033125.1; NM_001038036.2.
DR   RefSeq; XP_005216430.1; XM_005216373.1.
DR   UniGene; Bt.101231; -.
DR   ProteinModelPortal; Q32LN0; -.
DR   SMR; Q32LN0; 208-299.
DR   PRIDE; Q32LN0; -.
DR   Ensembl; ENSBTAT00000022792; ENSBTAP00000022792; ENSBTAG00000017150.
DR   GeneID; 505422; -.
DR   KEGG; bta:505422; -.
DR   CTD; 26298; -.
DR   eggNOG; NOG307806; -.
DR   GeneTree; ENSGT00750000117299; -.
DR   HOGENOM; HOG000232188; -.
DR   HOVERGEN; HBG074143; -.
DR   InParanoid; Q32LN0; -.
DR   KO; K17102; -.
DR   OMA; VMNLNPG; -.
DR   OrthoDB; EOG7M0NRR; -.
DR   TreeFam; TF318679; -.
DR   NextBio; 20867133; -.
DR   GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome.
DR   GO; GO:0030154; P:cell differentiation; IBA:RefGenome.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; IBA:GOC.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    300       ETS homologous factor.
FT                                /FTId=PRO_0000287132.
FT   DOMAIN       29    115       PNT.
FT   DNA_BIND    207    289       ETS.
SQ   SEQUENCE   300 AA;  35004 MW;  F20E8A1F0184DB86 CRC64;
     MILEGSGVMN LNPSNNLLHQ QPTWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ
     HLLDTNQLDA SCIPFQEFDV NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD
     LFQSTHNVIV KTEQTDPSIM NTWKEENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTGHLP
     IAESPDTKKE QDHPTKPHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGIFRFL
     KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
//
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