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Database: UniProt
Entry: EIF1B_HUMAN
LinkDB: EIF1B_HUMAN
Original site: EIF1B_HUMAN 
ID   EIF1B_HUMAN             Reviewed;         113 AA.
AC   O60739; Q9UQF8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-OCT-2017, entry version 143.
DE   RecName: Full=Eukaryotic translation initiation factor 1b;
DE            Short=eIF1b;
DE   AltName: Full=Protein translation factor SUI1 homolog GC20;
GN   Name=EIF1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RA   Zhao Z., Huang X., Li N., Zhu X., Cao X.;
RT   "Human dendritic cell SUI1 homolog gene.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=10931946; DOI=10.1073/pnas.160270997;
RA   Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA   Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H.,
RA   Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J.,
RA   Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M.,
RA   Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
RT   "Gene expression profiling in the human hypothalamus-pituitary-adrenal
RT   axis and full-length cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Kim D.-G., You K.-R.;
RT   "Homo sapiens translational factor eIF-1.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE
RP   SCALE ANALYSIS] AT SER-9, CLEAVAGE OF INITIATOR METHIONINE [LARGE
RP   SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Probably involved in translation.
CC   -!- SIMILARITY: Belongs to the SUI1 family. {ECO:0000305}.
DR   EMBL; AF064607; AAC17112.1; -; mRNA.
DR   EMBL; AF077052; AAD27785.1; -; mRNA.
DR   EMBL; AF263452; AAF79182.1; -; mRNA.
DR   EMBL; BC006996; AAH06996.1; -; mRNA.
DR   CCDS; CCDS2690.1; -.
DR   RefSeq; NP_005866.1; NM_005875.2.
DR   UniGene; Hs.315230; -.
DR   ProteinModelPortal; O60739; -.
DR   SMR; O60739; -.
DR   BioGrid; 115578; 37.
DR   IntAct; O60739; 5.
DR   STRING; 9606.ENSP00000232905; -.
DR   iPTMnet; O60739; -.
DR   PhosphoSitePlus; O60739; -.
DR   BioMuta; EIF1B; -.
DR   EPD; O60739; -.
DR   PaxDb; O60739; -.
DR   PeptideAtlas; O60739; -.
DR   PRIDE; O60739; -.
DR   TopDownProteomics; O60739; -.
DR   DNASU; 10289; -.
DR   Ensembl; ENST00000232905; ENSP00000232905; ENSG00000114784.
DR   GeneID; 10289; -.
DR   KEGG; hsa:10289; -.
DR   CTD; 10289; -.
DR   EuPathDB; HostDB:ENSG00000114784.3; -.
DR   GeneCards; EIF1B; -.
DR   HGNC; HGNC:30792; EIF1B.
DR   neXtProt; NX_O60739; -.
DR   OpenTargets; ENSG00000114784; -.
DR   PharmGKB; PA143485452; -.
DR   eggNOG; KOG1770; Eukaryota.
DR   eggNOG; COG0023; LUCA.
DR   GeneTree; ENSGT00390000015789; -.
DR   HOGENOM; HOG000279813; -.
DR   HOVERGEN; HBG000295; -.
DR   InParanoid; O60739; -.
DR   KO; K03113; -.
DR   OMA; QPTNYIH; -.
DR   OrthoDB; EOG091G10OC; -.
DR   PhylomeDB; O60739; -.
DR   TreeFam; TF314417; -.
DR   ChiTaRS; EIF1B; human.
DR   GeneWiki; EIF1B; -.
DR   GenomeRNAi; 10289; -.
DR   PRO; PR:O60739; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000114784; -.
DR   CleanEx; HS_EIF1B; -.
DR   ExpressionAtlas; O60739; baseline and differential.
DR   Genevisible; O60739; HS.
DR   GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006446; P:regulation of translational initiation; NAS:UniProtKB.
DR   CDD; cd11566; eIF1_SUI1; 1.
DR   Gene3D; 3.30.780.10; -; 1.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   InterPro; IPR005874; SUI1_euk.
DR   Pfam; PF01253; SUI1; 1.
DR   PIRSF; PIRSF004499; SUI1_euk; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   TIGRFAMs; TIGR01160; SUI1_MOF2; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Complete proteome; Initiation factor; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome.
FT   INIT_MET      1      1       Removed. {ECO:0000244|PubMed:21406692}.
FT   CHAIN         2    113       Eukaryotic translation initiation factor
FT                                1b.
FT                                /FTId=PRO_0000130558.
FT   MOD_RES       2      2       N-acetylserine.
FT                                {ECO:0000244|PubMed:21406692}.
FT   MOD_RES       9      9       Phosphoserine.
FT                                {ECO:0000244|PubMed:21406692,
FT                                ECO:0000244|PubMed:23186163}.
FT   CONFLICT     27     27       T -> L (in Ref. 1; AAC17112).
FT                                {ECO:0000305}.
FT   CONFLICT     41     41       R -> G (in Ref. 1; AAC17112).
FT                                {ECO:0000305}.
SQ   SEQUENCE   113 AA;  12824 MW;  4522A8B692654FE1 CRC64;
     MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
     KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV GIVKEEQLKV HGF
//
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