ID EIF3B_ANOGA Reviewed; 683 AA.
AC Q7PZY1;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 3.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=eIF3-S9 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=AGAP012140;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; AAAB01008986; EAA00199.3; -; Genomic_DNA.
DR RefSeq; XP_320387.3; XM_320387.4.
DR AlphaFoldDB; Q7PZY1; -.
DR SMR; Q7PZY1; -.
DR STRING; 7165.Q7PZY1; -.
DR PaxDb; 7165-AGAP012140-PA; -.
DR EnsemblMetazoa; AGAP012140-RA; AGAP012140-PA; AGAP012140.
DR GeneID; 1280537; -.
DR KEGG; aga:AgaP_AGAP012140; -.
DR CTD; 1280537; -.
DR VEuPathDB; VectorBase:AGAP012140; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_1_0_1; -.
DR InParanoid; Q7PZY1; -.
DR OMA; LWGGPQF; -.
DR OrthoDB; 5479191at2759; -.
DR PhylomeDB; Q7PZY1; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED; 1.
DR PANTHER; PTHR14068:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..683
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363791"
FT DOMAIN 49..133
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 199..238
FT /note="WD 1"
FT REPEAT 240..279
FT /note="WD 2"
FT REPEAT 283..321
FT /note="WD 3"
FT REPEAT 324..359
FT /note="WD 4"
FT REPEAT 435..477
FT /note="WD 5"
FT REPEAT 522..567
FT /note="WD 6"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 611..638
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 683 AA; 79411 MW; 06E3722B65CF21D5 CRC64;
MAKKKGEEQD FEEEPNFDDP EGFVDDVSDE ELLGDFLRQK PCESDGVENV IVVDNIPVVG
AARFPKLKGI IEKIFKNAGT IVNVHYPKDE EDNTKGYAFV EYKNQESAEE AVKSLNNYRL
DKHYTLLVNR FADFQKYSDI PKEWSPPQPQ PYKVQNDLYN FLLEADAQDQ FCVVSETVPG
SVQVQFCQNT QPEPTELLKR ERFTDTYVKW SPKGTYIVTF HKQGVVVWGG SSFVKVNKFA
HSNAQFVDIS PCEQYLVTYG PNGQKIVIWD IRTGAEKRTF VSDGMSNASM LRWSHDDRYV
ARLVDSQIQI YDTTTFFLLD MKSIRVEGIR NFSWSPTDNI IAYWVAEEVD VPAKVTLMAI
PKKTELRTKN LFNVADCKIH WQKSGDYLCV KVDRFSKSKK EKKDKKDSDV KFLGMFYNFE
IFHMREKDIP VDSVEVKETI LAFAWEPVGS KFSIIHGEPS SANVSFYETN KGQEPVLVKK
LEKKVCGHLF WSPRGQFIVL ANLQMGTFEF VDTNDFSIMK TGDHYRASEV EWDPTGRYVV
TGTSGKAKED QGYYMWSFQG RILKRVNLKN FMLFLWRPRP PTLLSDAKQK EILKNLKKYY
SQFESKDRLR MTRASKELIE KRAKLREQFT EYRSKRVKEW EDQKKRRMQL RNNVDTDTLE
ADPDNVEEEI VEILVREDTT VIE
//
