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Database: UniProt
Entry: EIF3E_MONBE
LinkDB: EIF3E_MONBE
Original site: EIF3E_MONBE 
ID   EIF3E_MONBE             Reviewed;         485 AA.
AC   A9UQS1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   07-JUN-2017, entry version 52.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004};
DE            Short=eIF3e {ECO:0000255|HAMAP-Rule:MF_03004};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000255|HAMAP-Rule:MF_03004};
GN   ORFNames=13685;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellida; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the
RT   origin of metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex, which is involved in protein synthesis
CC       of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi
CC       to the 40S ribosome. The eIF-3 complex specifically targets and
CC       initiates translation of a subset of mRNAs involved in cell
CC       proliferation. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor
CC       3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit E family.
CC       {ECO:0000255|HAMAP-Rule:MF_03004}.
DR   EMBL; CH991543; EDQ93095.1; -; Genomic_DNA.
DR   RefSeq; XP_001742857.1; XM_001742805.1.
DR   ProteinModelPortal; A9UQS1; -.
DR   SMR; A9UQS1; -.
DR   STRING; 431895.XP_001742857.1; -.
DR   EnsemblProtists; EDQ93095; EDQ93095; MONBRDRAFT_13685.
DR   GeneID; 5887340; -.
DR   KEGG; mbr:MONBRDRAFT_13685; -.
DR   eggNOG; KOG2758; Eukaryota.
DR   eggNOG; ENOG410XQK5; LUCA.
DR   InParanoid; A9UQS1; -.
DR   KO; K03250; -.
DR   OMA; GFFRTQV; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_03004; eIF3e; 1.
DR   InterPro; IPR016650; eIF3e.
DR   InterPro; IPR019010; eIF3e_N.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   PANTHER; PTHR10317; PTHR10317; 1.
DR   Pfam; PF09440; eIF3_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PIRSF; PIRSF016255; eIF3e_su6; 1.
DR   SMART; SM01186; eIF3_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN         1    485       Eukaryotic translation initiation factor
FT                                3 subunit E.
FT                                /FTId=PRO_0000365994.
FT   DOMAIN      284    388       PCI. {ECO:0000255|HAMAP-Rule:MF_03004}.
SQ   SEQUENCE   485 AA;  55760 MW;  6E1576B6E0D02C5D CRC64;
     MAAHDLTQAI CQNLDPHLIL PLLDHCVDLD IYNEADLKRA KMQVLSRTRL IEQALELADA
     TEKKDLDARM RSISEEEKTW EKQLEPVFEM FENDEVLSII EATKNKDSLL SELEPYGFTE
     NTADLLYHGS KFYFDRGQYD LAHGLLYNYR AVSTDDKLKF TALWGKLAAA ILSGNWQTAQ
     EDMYLLLEYI DGGKNELTAV EQLQQRNWLL HWSLFVFFNQ PDGPDGIVDL FMNKETCTNA
     MQTIAPHLFR YATAVAIMSR RKKRDVMWEF VGIARQDKDL GDDPVVGFLV SLIKDFDFVT
     AEEKLQQCRE VLSKDYFLAE MTDEFINTAQ LYLFEVYLRV HSRVSIKNAA TRLGKSEDDA
     EEWLVKLIRD AKLDAQIDPA SGEIHITKPV TTVYQHVLDR TKNLQYRTYV IVESLHHLHP
     NGAFHHSNSS IPALFRRMMN EQLQGGGKSN KKGDYKKGDY KKGGDFKKGG DFKKGGDHKK
     RAWVK
//
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