ID   EPO_MICOE               Reviewed;         192 AA.
AC   Q0Z956;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   06-MAR-2013, entry version 29.
DE   RecName: Full=Erythropoietin;
DE   Flags: Precursor;
GN   Name=EPO;
OS   Microtus oeconomus (Tundra vole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Arvicolinae; Microtus.
OX   NCBI_TaxID=64717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RA   Wang Y., Chen X.-Q., Du J.-Z.;
RT   "Cloning of erythropoietin cDNA from root vole (Microtus oeconomus).";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC       regulation of erythrocyte differentiation and the maintenance of a
CC       physiological level of circulating erythrocyte mass (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Produced by kidney or liver of adult mammals
CC       and by liver of fetal or neonatal mammals.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family.
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DR   EMBL; DQ658370; ABG47336.1; -; mRNA.
DR   ProteinModelPortal; Q0Z956; -.
DR   SMR; Q0Z956; 27-192.
DR   HOVERGEN; HBG003978; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR019767; EPO/TPO_CS.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003013; Erythroptn.
DR   PANTHER; PTHR10370; PTHR10370; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PIRSF; PIRSF001951; EPO; 1.
DR   PRINTS; PR00272; ERYTHROPTN.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00817; EPO_TPO; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Erythrocyte maturation; Glycoprotein; Hormone;
KW   Secreted; Signal.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    192       Erythropoietin.
FT                                /FTId=PRO_0000313663.
FT   CARBOHYD     50     50       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     64     64       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    109    109       N-linked (GlcNAc...) (Potential).
FT   DISULFID     33    187       By similarity.
SQ   SEQUENCE   192 AA;  21232 MW;  E29C578F32AE0497 CRC64;
     MGVPERPTLL LLLSLLLLPL GLPVLCAPPR LICDGRVLER YILEAREAEN VTMGCAEGPR
     LSENITVPDT KVNFNAWKRM EVQEQAVEVW QGLSLLSEAI LRGQALLANS SQPSGMLQLH
     IDKAISGLRS LTSLLRVLGA QKESISPPDA TPPAPLRTLM VENFCKLFRV YSNFLRGKLK
     LYTGEACRRG DR
//