ID EPO_PIG Reviewed; 194 AA.
AC P49157; Q9MYM8;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 03-APR-2013, entry version 77.
DE RecName: Full=Erythropoietin;
DE Flags: Precursor;
GN Name=EPO;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Norwegian Landrace; TISSUE=Kidney;
RX PubMed=11311851; DOI=10.1016/S0739-7240(01)00089-3;
RA David R.B., Blom A.K., Sjaastad O.V., Harbitz I.;
RT "The porcine erythropoietin gene: cDNA sequence, genomic sequence and
RT expression analyses in piglets.";
RL Domest. Anim. Endocrinol. 20:137-147(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-194.
RC TISSUE=Kidney;
RX PubMed=8364201;
RA Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S.,
RA Czelusniak J., Goodman M., Bunn H.F.;
RT "Erythropoietin structure-function relationships: high degree of
RT sequence homology among mammals.";
RL Blood 82:1507-1516(1993).
CC -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC regulation of erythrocyte differentiation and the maintenance of a
CC physiological level of circulating erythrocyte mass.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by kidney or liver of adult mammals
CC and by liver of fetal or neonatal mammals.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
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DR EMBL; AJ249745; CAB96416.1; -; mRNA.
DR EMBL; AJ249746; CAB96417.1; -; Genomic_DNA.
DR EMBL; L10607; AAA31029.1; -; mRNA.
DR PIR; I46578; I46578.
DR RefSeq; NP_999299.1; NM_214134.1.
DR UniGene; Ssc.15896; -.
DR ProteinModelPortal; P49157; -.
DR SMR; P49157; 27-194.
DR STRING; 9823.ENSSSCP00000008194; -.
DR Ensembl; ENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673.
DR GeneID; 397249; -.
DR KEGG; ssc:397249; -.
DR CTD; 2056; -.
DR eggNOG; NOG43828; -.
DR GeneTree; ENSGT00390000017226; -.
DR HOGENOM; HOG000052505; -.
DR HOVERGEN; HBG003978; -.
DR KO; K05437; -.
DR OMA; NVTMGCA; -.
DR OrthoDB; EOG41VK4C; -.
DR GO; GO:0005615; C:extracellular space; IEA:Compara.
DR GO; GO:0043499; F:eukaryotic cell surface binding; IEA:Compara.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:Compara.
DR GO; GO:0006915; P:apoptotic process; IEA:Compara.
DR GO; GO:0071474; P:cellular hyperosmotic response; IEA:Compara.
DR GO; GO:0007566; P:embryo implantation; IEA:Compara.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Compara.
DR GO; GO:0032413; P:negative regulation of ion transmembrane transporter activity; IEA:Compara.
DR GO; GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Compara.
DR GO; GO:0010766; P:negative regulation of sodium ion transport; IEA:Compara.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
DR GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
DR GO; GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Compara.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
DR GO; GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IEA:Compara.
DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
DR GO; GO:0001666; P:response to hypoxia; IEA:Compara.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR019767; EPO/TPO_CS.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003013; Erythroptn.
DR PANTHER; PTHR10370; PTHR10370; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PIRSF; PIRSF001951; EPO; 1.
DR PRINTS; PR00272; ERYTHROPTN.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00817; EPO_TPO; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Disulfide bond; Erythrocyte maturation;
KW Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1 26 Potential.
FT CHAIN 27 194 Erythropoietin.
FT /FTId=PRO_0000008406.
FT CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
FT DISULFID 33 189 By similarity.
FT DISULFID 55 59 By similarity.
SQ SEQUENCE 194 AA; 21304 MW; 77881A6F6F20EA1C CRC64;
MGARECPARL LLLSLLLLPL GLPVLGAPPR LICDSRVLER YILEAKEGEN ATMGCAESCS
FSENITVPDT KVNFYAWKRM EVQQQAMEVW QGLALLSEAI LQGQALLANS SQPSEALQLH
VDKAVSGLRS LTSLLRALGA QKEAIPLPDA SPSSATPLRT FAVDTLCKLF RNYSNFLRGK
LTLYTGEACR RRDR
//
