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Database: UniProt
Entry: EPO_PIG
LinkDB: EPO_PIG
Original site: EPO_PIG 
ID   EPO_PIG                 Reviewed;         194 AA.
AC   P49157; Q9MYM8;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   19-FEB-2014, entry version 81.
DE   RecName: Full=Erythropoietin;
DE   Flags: Precursor;
GN   Name=EPO;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Norwegian Landrace; TISSUE=Kidney;
RX   PubMed=11311851; DOI=10.1016/S0739-7240(01)00089-3;
RA   David R.B., Blom A.K., Sjaastad O.V., Harbitz I.;
RT   "The porcine erythropoietin gene: cDNA sequence, genomic sequence and
RT   expression analyses in piglets.";
RL   Domest. Anim. Endocrinol. 20:137-147(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 5-194.
RC   TISSUE=Kidney;
RX   PubMed=8364201;
RA   Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S.,
RA   Czelusniak J., Goodman M., Bunn H.F.;
RT   "Erythropoietin structure-function relationships: high degree of
RT   sequence homology among mammals.";
RL   Blood 82:1507-1516(1993).
CC   -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC       regulation of erythrocyte differentiation and the maintenance of a
CC       physiological level of circulating erythrocyte mass.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by kidney or liver of adult mammals
CC       and by liver of fetal or neonatal mammals.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family.
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DR   EMBL; AJ249745; CAB96416.1; -; mRNA.
DR   EMBL; AJ249746; CAB96417.1; -; Genomic_DNA.
DR   EMBL; L10607; AAA31029.1; -; mRNA.
DR   PIR; I46578; I46578.
DR   RefSeq; NP_999299.1; NM_214134.1.
DR   UniGene; Ssc.15896; -.
DR   ProteinModelPortal; P49157; -.
DR   SMR; P49157; 27-194.
DR   STRING; 9823.ENSSSCP00000008194; -.
DR   Ensembl; ENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673.
DR   GeneID; 397249; -.
DR   KEGG; ssc:397249; -.
DR   CTD; 2056; -.
DR   eggNOG; NOG43828; -.
DR   GeneTree; ENSGT00390000017226; -.
DR   HOGENOM; HOG000052505; -.
DR   HOVERGEN; HBG003978; -.
DR   KO; K05437; -.
DR   OMA; NVTMGCA; -.
DR   OrthoDB; EOG7DVDCR; -.
DR   TreeFam; TF333413; -.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:0071474; P:cellular hyperosmotic response; IEA:Ensembl.
DR   GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR   GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR   GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
DR   GO; GO:2001258; P:negative regulation of cation channel activity; IEA:Ensembl.
DR   GO; GO:1902251; P:negative regulation of erythrocyte apoptotic process; IEA:Ensembl.
DR   GO; GO:1902219; P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR019767; EPO/TPO_CS.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003013; Erythroptn.
DR   PANTHER; PTHR10370; PTHR10370; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PIRSF; PIRSF001951; EPO; 1.
DR   PRINTS; PR00272; ERYTHROPTN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00817; EPO_TPO; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Erythrocyte maturation;
KW   Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    194       Erythropoietin.
FT                                /FTId=PRO_0000008406.
FT   CARBOHYD     50     50       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     64     64       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    109    109       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    172    172       N-linked (GlcNAc...) (Potential).
FT   DISULFID     33    189       By similarity.
FT   DISULFID     55     59       By similarity.
SQ   SEQUENCE   194 AA;  21304 MW;  77881A6F6F20EA1C CRC64;
     MGARECPARL LLLSLLLLPL GLPVLGAPPR LICDSRVLER YILEAKEGEN ATMGCAESCS
     FSENITVPDT KVNFYAWKRM EVQQQAMEVW QGLALLSEAI LQGQALLANS SQPSEALQLH
     VDKAVSGLRS LTSLLRALGA QKEAIPLPDA SPSSATPLRT FAVDTLCKLF RNYSNFLRGK
     LTLYTGEACR RRDR
//
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