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Database: UniProt
Entry: EPO_TETNG
LinkDB: EPO_TETNG
Original site: EPO_TETNG 
ID   EPO_TETNG               Reviewed;         180 AA.
AC   Q4T554; Q6UAM1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   01-OCT-2014, entry version 50.
DE   RecName: Full=Erythropoietin;
DE   Flags: Precursor;
GN   Name=epo; ORFNames=GSTENG00006991001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Percomorpharia; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lutfalla G.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC       regulation of erythrocyte differentiation and the maintenance of a
CC       physiological level of circulating erythrocyte mass.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAR25698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY374507; AAR25698.1; ALT_INIT; mRNA.
DR   EMBL; CAAE01009425; CAF91978.1; -; Genomic_DNA.
DR   STRING; 99883.ENSTNIP00000004178; -.
DR   Ensembl; ENSTNIT00000004312; ENSTNIP00000004178; ENSTNIG00000000863.
DR   eggNOG; COG0386; -.
DR   GeneTree; ENSGT00390000017226; -.
DR   HOGENOM; HOG000277054; -.
DR   HOVERGEN; HBG003978; -.
DR   InParanoid; Q4T554; -.
DR   TreeFam; TF333413; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR   GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003013; Erythroptn.
DR   PANTHER; PTHR10370; PTHR10370; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PIRSF; PIRSF001951; EPO; 1.
DR   PRINTS; PR00272; ERYTHROPTN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Erythrocyte maturation;
KW   Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    180       Erythropoietin.
FT                                /FTId=PRO_0000313668.
FT   CARBOHYD     75     75       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     27    175       {ECO:0000250}.
FT   DISULFID     49     53       {ECO:0000250}.
SQ   SEQUENCE   180 AA;  19948 MW;  7FB251FCC54BD48F CRC64;
     MTGLLAFLLI VLEWTRPSLP SPLRPICDLR VLNHFIKEAQ DAEAAMKTCR EGCTLSESVV
     VPQTTVDFDV WEKKNASAKA EEVQSGLWLL QQAFNFLRTS VTNAALHSHI DNAVRNLLSV
     NAVLRSLNIQ EFTPQANGAE IEGTWRASSA AELLQVYVNF LRGKARLLLL DAQACQQDVS
//
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