ID EPO_TETNG Reviewed; 180 AA.
AC Q4T554; Q6UAM1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 06-MAR-2013, entry version 42.
DE RecName: Full=Erythropoietin;
DE Flags: Precursor;
GN Name=epo; ORFNames=GSTENG00006991001;
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes;
OC Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lutfalla G.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT the early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
CC -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC regulation of erythrocyte differentiation and the maintenance of a
CC physiological level of circulating erythrocyte mass (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAR25698.1; Type=Erroneous initiation;
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DR EMBL; AY374507; AAR25698.1; ALT_INIT; mRNA.
DR EMBL; CAAE01009425; CAF91978.1; -; Genomic_DNA.
DR HSSP; P01588; 1BUY.
DR Ensembl; ENSTNIT00000004312; ENSTNIP00000004178; ENSTNIG00000000863.
DR eggNOG; COG0386; -.
DR GeneTree; ENSGT00390000017226; -.
DR HOGENOM; HOG000277054; -.
DR HOVERGEN; HBG003978; -.
DR InParanoid; Q4T554; -.
DR OrthoDB; EOG4TXBSZ; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR GO; GO:0006950; P:response to stress; IEA:Compara.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003013; Erythroptn.
DR PANTHER; PTHR10370; PTHR10370; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PIRSF; PIRSF001951; EPO; 1.
DR PRINTS; PR00272; ERYTHROPTN.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Disulfide bond; Erythrocyte maturation;
KW Glycoprotein; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1 20 Potential.
FT CHAIN 21 180 Erythropoietin.
FT /FTId=PRO_0000313668.
FT CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
FT DISULFID 27 175 By similarity.
FT DISULFID 49 53 By similarity.
SQ SEQUENCE 180 AA; 19948 MW; 7FB251FCC54BD48F CRC64;
MTGLLAFLLI VLEWTRPSLP SPLRPICDLR VLNHFIKEAQ DAEAAMKTCR EGCTLSESVV
VPQTTVDFDV WEKKNASAKA EEVQSGLWLL QQAFNFLRTS VTNAALHSHI DNAVRNLLSV
NAVLRSLNIQ EFTPQANGAE IEGTWRASSA AELLQVYVNF LRGKARLLLL DAQACQQDVS
//
