ID EV45_HHV11 Reviewed; 172 AA.
AC P10229; Q09I89;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-APR-2013, entry version 52.
DE RecName: Full=Envelope protein UL45;
DE AltName: Full=18 kDa protein;
GN ORFNames=UL45;
OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS 1).
OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10299;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2839594;
RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA McNab D., Perry L.J., Scott J.E., Taylor P.;
RT "The complete DNA sequence of the long unique region in the genome of
RT herpes simplex virus type 1.";
RL J. Gen. Virol. 69:1531-1574(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nonneuroinvasive mutant HF10;
RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT "Determination and analysis of the DNA sequence of highly attenuated
RT herpes simplex virus type 1 mutant HF10, a potential oncolytic
RT virus.";
RL Microbes Infect. 9:142-149(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17 syn+;
RA Cunningham C., Davison A.J.;
RT "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION.
RX PubMed=8057463;
RA Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.;
RT "The UL45 gene product is required for herpes simplex virus type 1
RT glycoprotein B-induced fusion.";
RL J. Virol. 68:5825-5834(1994).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=F;
RX PubMed=18596102; DOI=10.1128/JVI.00904-08;
RA Loret S., Guay G., Lippe R.;
RT "Comprehensive characterization of extracellular herpes simplex virus
RT type 1 virions.";
RL J. Virol. 82:8605-8618(2008).
CC -!- FUNCTION: Important virulence factor of HSV neurotropism. Seems to
CC be required for glycoprotein B-induced fusion. Dispensable for
CC growth in vitro (By similarity).
CC -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type II
CC membrane protein. Note=In transfected cells, it is retained within
CC the ER (By similarity).
CC -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X14112; CAA32295.1; -; Genomic_DNA.
DR EMBL; DQ889502; ABI63506.1; -; Genomic_DNA.
DR EMBL; FJ593289; ACM62268.1; -; Genomic_DNA.
DR PIR; I30088; WMBEF5.
DR RefSeq; NP_044647.1; NC_001806.1.
DR GeneID; 2703412; -.
DR ProtClustDB; CLSP2510165; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018002; Herpes_UL45.
DR InterPro; IPR008646; Herpes_UL45-like.
DR Pfam; PF05473; Herpes_UL45; 1.
DR PIRSF; PIRSF003509; Herpes_UL45; 1.
PE 3: Inferred from homology;
KW Complete proteome; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
FT CHAIN 1 172 Envelope protein UL45.
FT /FTId=PRO_0000116086.
FT TOPO_DOM 1 27 Intravirion (Potential).
FT TRANSMEM 28 48 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 49 172 Virion surface (Potential).
SQ SEQUENCE 172 AA; 18180 MW; EA57EF40D40003D7 CRC64;
MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD
SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS
GDGIRACLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP
//
