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Database: UniProt
Entry: EX7L_NOCFA
LinkDB: EX7L_NOCFA
Original site: EX7L_NOCFA 
ID   EX7L_NOCFA              Reviewed;         425 AA.
AC   Q5YQ92;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-OCT-2017, entry version 96.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378};
GN   OrderedLocusNames=NFA_47970;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
DR   EMBL; AP006618; BAD59649.1; -; Genomic_DNA.
DR   RefSeq; WP_011211333.1; NC_006361.1.
DR   SMR; Q5YQ92; -.
DR   STRING; 247156.nfa47970; -.
DR   EnsemblBacteria; BAD59649; BAD59649; NFA_47970.
DR   KEGG; nfa:NFA_47970; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Exonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN         1    425       Exodeoxyribonuclease 7 large subunit.
FT                                /FTId=PRO_0000303806.
SQ   SEQUENCE   425 AA;  45777 MW;  A868F597B7B6A870 CRC64;
     MTQDGSAPAN SAEHPWPVRS VSVKVMQWID RLGSIWVEGQ ITQINLRPGA RTAFLVLRDP
     SADMSLQVTC DPELIRRSPV PLQEGSRVVV YGKLVFFPAR GSISLRVLEI RPVGVGELLA
     RIERLKALLA AEGLFDERLK RPIPFLPKVV GLITGRGGAA EHDVLTVARN RWPAVRFEVR
     NTAVQGPTAV PQILTALAEL DRHPEVEVIV LARGGGSVED LLPFSDEALC RAIVAATTPI
     VSAIGHEPDN PLSDYVADLR AATPTDAAKR VVPDAAAELA LVRELRARSA AALRGWVDRE
     ARALAQLRSR PVLADPLREI DRRATEIERL RADARRCVRH LIRTESTATA HLREKLTAVG
     PAATLARGYA VVQRVTGPER HVVRSIADSP AGSQLRIRVA DGAVSAAALG TTAAGTRIAD
     DTGGN
//
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