ID EZRA_ENTFA Reviewed; 578 AA.
AC Q838R5;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=EF_0370;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC Note=Colocalized with FtsZ to the nascent septal site.
CC {ECO:0000255|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00728}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016830; AAO80232.1; -; Genomic_DNA.
DR RefSeq; NP_814161.1; NC_004668.1.
DR RefSeq; WP_002355233.1; NZ_KE136524.1.
DR AlphaFoldDB; Q838R5; -.
DR SMR; Q838R5; -.
DR STRING; 226185.EF_0370; -.
DR EnsemblBacteria; AAO80232; AAO80232; EF_0370.
DR GeneID; 60892822; -.
DR KEGG; efa:EF0370; -.
DR PATRIC; fig|226185.45.peg.2959; -.
DR eggNOG; COG4477; Bacteria.
DR HOGENOM; CLU_034079_2_0_9; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT CHAIN 1..578
FT /note="Septation ring formation regulator EzrA"
FT /id="PRO_0000172871"
FT TOPO_DOM 1..8
FT /note="Extracellular"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT TRANSMEM 9..27
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT TOPO_DOM 28..578
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 103..165
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 256..285
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 394..490
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ SEQUENCE 578 AA; 68153 MW; 6E35951442889F76 CRC64;
MKNNWIIILV LVIVIIAAVL YLIGYFMRKK NQEQLDELEV RKEALFDLPV FEEIDDIKKM
HLVGQSQNSF REWNQRWVEL STRSFAELES QIYEVENQNE IFRFMKAKKA VVEANETMTE
MEAEVEVIRN GLKELRESEE RNSLEVQKAL DVYEELSKSL KDDKASFGPA YSEIQKQLRN
VEIEFTQFVT LNTSGDPIEA REVLEDAERH TYELEDLMKR IPPMYEELNE TFPDQLKEIE
EGYNQLLADD YVFPEQNFAE EIQHAKKRVE NSMADLEKTE IAAVEVANRD TATAIDALYE
VMEREIEAKK YVVTNQKIID DYISHSLKNN RQLMIELDHV SQSYTLNNNE LGRSRGFQTE
IEEIIRRQKD LEPRMKEHTV PYSEIQAFYK ECYKILDDIE NQQLEIDASL KELRKGEKVA
QEKVDEYEFR LRSIKRYVEK QRLPGLSADY LEFFYVATDR IEDLSRALNK MRINMDEINR
LCDLCEDDLE LLDKKTKDLV NAAALTEQMM QYANRYRHTH ENIRAALDKS MYLFSTEFRY
QDALDEIGTA LEAVEPGAFK RIEDFYFKNI NNPNLTAI
//
