ID F0EFK5_ENTCA Unreviewed; 808 AA.
AC F0EFK5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Urocanate reductase {ECO:0000256|RuleBase:RU366062};
DE EC=1.3.99.33 {ECO:0000256|RuleBase:RU366062};
GN ORFNames=HMPREF9087_0507 {ECO:0000313|EMBL:EGC71130.1};
OS Enterococcus casseliflavus ATCC 12755.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=888066 {ECO:0000313|EMBL:EGC71130.1, ECO:0000313|Proteomes:UP000004835};
RN [1] {ECO:0000313|EMBL:EGC71130.1, ECO:0000313|Proteomes:UP000004835}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12755 {ECO:0000313|EMBL:EGC71130.1,
RC ECO:0000313|Proteomes:UP000004835};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + dihydrourocanate = AH2 + urocanate; Xref=Rhea:RHEA:36059,
CC ChEBI:CHEBI:13193, ChEBI:CHEBI:17499, ChEBI:CHEBI:27247,
CC ChEBI:CHEBI:72991; EC=1.3.99.33;
CC Evidence={ECO:0000256|RuleBase:RU366062};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|RuleBase:RU366062};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|RuleBase:RU366062};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|RuleBase:RU366062};
CC Note=Binds 1 FMN covalently per subunit.
CC {ECO:0000256|RuleBase:RU366062};
CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
CC FRD/SDH subfamily. {ECO:0000256|RuleBase:RU366062}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC71130.1}.
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DR EMBL; AEWT01000002; EGC71130.1; -; Genomic_DNA.
DR RefSeq; WP_005232825.1; NZ_GL872323.1.
DR AlphaFoldDB; F0EFK5; -.
DR HOGENOM; CLU_011398_4_0_9; -.
DR Proteomes; UP000004835; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.90.1010.20; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010960; Flavocytochrome_c.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR007329; FMN-bd.
DR InterPro; IPR005025; FMN_Rdtase-like.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01813; flavo_cyto_c; 1.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 2.
DR Pfam; PF04205; FMN_bind; 1.
DR Pfam; PF03358; FMN_red; 1.
DR SMART; SM00900; FMN_bind; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU366062};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU366062};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU366062}.
FT DOMAIN 201..275
FT /note="FMN-binding"
FT /evidence="ECO:0000259|SMART:SM00900"
SQ SEQUENCE 808 AA; 87567 MW; AE428FD5C017A943 CRC64;
MKFVGLIGTN AKKSTNRQLV AFMQREFAAL AEIELLEIKD VPMFNETQDQ TNSEVIQRLN
SKILAADGVI IATPEHNHSI PSALKSVLEW LSFNLHPFDG KPVMIVGASY DVQGSSRAQL
HLRQILDAPG VNATVMPGNE FLLGRAHQAF DEQGNLKDQR TIDFLESCFR KFVRFTEVAN
LLNVPEEVVY EPGEYTVTAL GHNGDLPMVV KLSEERIEAI DIDTSGESEG IADVVFVRIP
QEIIEGQTLN VDAISGASVT SNGVVDGVAK AVKMAGANPD VLRKRPKAAS ALQTEDETYT
TDVVVVGGGG AGLSAAASVL QANKDVILVE KFPAIGGNTV RTGGPMNAAD PKWQNGFSAL
PGERSALEEV LTIDEQDIDA EYLPDFKALK AQITAYLSET TPEKEYLFDS ALWHRIQTYL
GGKRKDLNGQ PIYGKYELVK ILTDQALASV KWLEEIGVEF DMNNVDMPVG AKWRRGHKPV
KNEGYAFVSA LHQFVKEHGG TILTDTPVKE LLIEDGKVTG IIGEGRNGQK ITIHAKAVIL
ASGGFGANTK MLKQYNTYWT EIEDDIKTSN SPAITGDGIK LGESAGADLV GMGFSQMMPV
SDPNTGALFS GLQVPPANFV MVNQKGERFV NEYESRDVLT QAAIDNGGLF YLIADEEIKK
TAYNTSQEKI DKQVAAGTLF RSETLAGLAE QINVDPTVLE ATVAKYNSYV DAGKDPEFGK
DVFDLKVEKA PFYATPRKPA VHHTMGGLKI DPQTHVLTKE DQIIEGLYAA GEVAGGIHAG
NRLGGNSLTD IFTFGRIAGK TAVAEHLE
//