ID F0F0P8_9NEIS Unreviewed; 923 AA.
AC F0F0P8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EGC16880.1};
GN ORFNames=HMPREF9098_1683 {ECO:0000313|EMBL:EGC16880.1};
OS Kingella denitrificans ATCC 33394.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Kingella.
OX NCBI_TaxID=888741 {ECO:0000313|EMBL:EGC16880.1, ECO:0000313|Proteomes:UP000004088};
RN [1] {ECO:0000313|EMBL:EGC16880.1, ECO:0000313|Proteomes:UP000004088}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33394 {ECO:0000313|EMBL:EGC16880.1,
RC ECO:0000313|Proteomes:UP000004088};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC16880.1}.
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DR EMBL; AEWV01000030; EGC16880.1; -; Genomic_DNA.
DR AlphaFoldDB; F0F0P8; -.
DR STRING; 888741.HMPREF9098_1683; -.
DR HOGENOM; CLU_002472_4_0_4; -.
DR Proteomes; UP000004088; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000004088}.
FT DOMAIN 757..773
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 683..690
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 923 AA; 101834 MW; 2B695B1617F5D5F1 CRC64;
MVNRWHIFIP VEKYLAGTMP ASRALSRYNK QFVNLLCCLA GCRLLFVSDL PQSSLHGKCA
GGAKTVKICG RHEISGKFMT IKPLSPMMQQ YLAIKAEHQD KLVFYRMGDF YELFFDDAVK
AAKLLDITLT TRGQCNGEPI KMAGVPYHAA EQYLVKLVKL GESVAICEQV GEVGAGKVVE
RKVVRIVTAG TLTDSALLED KQTNRIAALF AGKKQAALAW AALESGEFCV KIIPIERLAD
ELARLQVSEL LADAAFKLPE NCPKIPVSRL HHWQFAPDAA FALLTDYFGC QDLRAFGLDL
AQHSAAISAA GALLNYLKTT QNQLPPHMDA LVLEHESQFV AMNAATRRNL EVTQTLQGQP
APTLFSVLDN CMTNMGSRLL AHWLHHPLRH RPHIQARLDA VEALRRHGGD DVAGCLKKMA
DIERIAARIA LGSARPRDLS ALRDSLSVLQ DIHLPQSSLL DTLAGCFPET QGVAKLLQAA
LLPEPSVWLK DGGVINHGYH AELDELRHLQ THGDDALREL EERERQRTQL STLKVEYNRV
HGFYIELSKN QAEEAPADYQ RRQTLKNTER FITPELKAFE DKFLAAQERA LALEKTLFEQ
LLGSLQTELP RIQKAAKAAA TLDVLDGFAR TARERQYTMP EFCSGSEIHI RAGRHPVVER
QVAHFTPNDT DLDEARKLCL LTGPNMGGKS TYMRQTALIV LLAHTGSFVP AEHAKIGSID
QIFTRIGASD DLAGNRSTFM VEMSETAYIL HNATPQSLVL MDEVGRGTST FDGLALAHAA
AEHLLQKNGS LSLFATHYFE LTQLPNQYAA AFNSHLSALE QGHDIVFLHN VQNGAAEKSY
GIAVAKLAGL PARALKAAQR QLKQLEQQTA DRQLDLFAAP PEEADAPVAE NPVLQQLAAV
NPDELTPRQA LDVLYRLKAA AEE
//
