ID F0F2S4_9NEIS Unreviewed; 483 AA.
AC F0F2S4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN Name=algA {ECO:0000313|EMBL:EGC16086.1};
GN ORFNames=HMPREF9098_2409 {ECO:0000313|EMBL:EGC16086.1};
OS Kingella denitrificans ATCC 33394.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Kingella.
OX NCBI_TaxID=888741 {ECO:0000313|EMBL:EGC16086.1, ECO:0000313|Proteomes:UP000004088};
RN [1] {ECO:0000313|EMBL:EGC16086.1, ECO:0000313|Proteomes:UP000004088}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33394 {ECO:0000313|EMBL:EGC16086.1,
RC ECO:0000313|Proteomes:UP000004088};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC16086.1}.
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DR EMBL; AEWV01000046; EGC16086.1; -; Genomic_DNA.
DR RefSeq; WP_003784685.1; NZ_GL870929.1.
DR AlphaFoldDB; F0F2S4; -.
DR STRING; 888741.HMPREF9098_2409; -.
DR HOGENOM; CLU_035527_1_0_4; -.
DR Proteomes; UP000004088; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:EGC16086.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:EGC16086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004088};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EGC16086.1}.
FT DOMAIN 7..297
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 328..478
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 483 AA; 53399 MW; 9FDD05870D5912A9 CRC64;
MSSPIVPVIL SGGSGSRLWP LSRTAYPKQF LSLGGDCSLF QQSVARITSL VQAALPVSPP
IVVTNEEHRF LVADQLKAFS WQTQIVLEPA ARNTAPALTL AALAAAEQGD DPILVVTPSD
HLVADNKAFV QAVCRAVGKA EDGSIVILGV TPDKPETAYG YIQAQAQEED GIYTVAQFVE
KPDAATAEYY LGAGCFYWNA GLFILKASTW LKAIEQFRED IFKAACTTWR QRSTDQLDNI
RFIRPDAESF AQIPSESIDY AVMEPCAQSD IPISMVALDA GWSDLGSWDA VWQSLPKNEN
GNAIIGDGMA VQAQNNLIYA DRKLVSVVGV DNLIVVETAD AVLITDHAHS QNVKQLVGEL
ERQIRPEVKI HRKVYRPWGW YDSVDEDERF KVKRIGVNVG ASLSLQKHYH RAEHWIVVKG
TAEVTRGDEV ILLTENQSVY IPLGEKHRLH NVGRIPLELI EVQTGSYLEE DDIVRYQDNF
GRC
//
