ID F0FE27_STRSA Unreviewed; 574 AA.
AC F0FE27;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728,
GN ECO:0000313|EMBL:EGC22862.1};
GN ORFNames=HMPREF9388_0959 {ECO:0000313|EMBL:EGC22862.1};
OS Streptococcus sanguinis SK353.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888815 {ECO:0000313|EMBL:EGC22862.1, ECO:0000313|Proteomes:UP000004185};
RN [1] {ECO:0000313|EMBL:EGC22862.1, ECO:0000313|Proteomes:UP000004185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK353 {ECO:0000313|EMBL:EGC22862.1,
RC ECO:0000313|Proteomes:UP000004185};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC22862.1}.
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DR EMBL; AEWY01000004; EGC22862.1; -; Genomic_DNA.
DR RefSeq; WP_002897820.1; NZ_GL872307.1.
DR AlphaFoldDB; F0FE27; -.
DR PATRIC; fig|888815.3.peg.940; -.
DR HOGENOM; CLU_034079_2_0_9; -.
DR Proteomes; UP000004185; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TOPO_DOM 27..574
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 117..183
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 268..342
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 381..415
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 574 AA; 65961 MW; C3EFE12510CBD7F1 CRC64;
MSIGLVILVA VVALLLVVGY GTAVLMRKRN EALLQNLEER KEALYNLPVN DEVEEVKNMH
LIGQSQVAFR EWNQKWVDLS LNSFADIENN LFEAEGYNNS FRFIKAKHAI GNIESQIDLI
EEDIKMIRAA LEDLKEQESK NSGRVLHALD LFEKLQTQVA ENADSYGQAL AEIEKQLENI
QSEFSQFVTL NSSGDPVEAA EILDKAEDHI LALTHIVEKV PAIVEELTVK LPDQLEDLES
GHRKLLESGY HFIETDIESR FQQLHASLKR NEANISALEL DNAEYENEQA QEEINALYEI
FTREIEAHKV VEKLIKNLPS YLAHTKENNQ QLQKEIERLS QTFLLSDTET SHVKELQAEL
SAQEDVVLSA VEDSSETKQA YSVVQEELEA IQERLKEIED EQISLGEALA EIEKDDANAR
QKVNIYANKL HTIKRYMEKR NLPGIPDSFL EIFFSTSNNI EELVKELEAT RVNIESVNRW
LEILGNDMEQ LEEETYRIVQ DATLTEQLLQ YSNRYRSFDD NVQAAFNKSL YVFEHDYDYA
QSLEIISKAL DLVEPGVTER FVTSYEKTRE NIRF
//