ID F0FTA2_STRSA Unreviewed; 449 AA.
AC F0FTA2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Trk system potassium uptake protein TrkA {ECO:0000256|ARBA:ARBA00017378};
GN Name=trkA {ECO:0000313|EMBL:EGC26931.1};
GN ORFNames=HMPREF9392_1834 {ECO:0000313|EMBL:EGC26931.1};
OS Streptococcus sanguinis SK678.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888819 {ECO:0000313|EMBL:EGC26931.1, ECO:0000313|Proteomes:UP000003133};
RN [1] {ECO:0000313|EMBL:EGC26931.1, ECO:0000313|Proteomes:UP000003133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK678 {ECO:0000313|EMBL:EGC26931.1,
RC ECO:0000313|Proteomes:UP000003133};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC26931.1}.
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DR EMBL; AEXA01000006; EGC26931.1; -; Genomic_DNA.
DR RefSeq; WP_002899748.1; NZ_GL872319.1.
DR AlphaFoldDB; F0FTA2; -.
DR GeneID; 61536986; -.
DR PATRIC; fig|888819.3.peg.1801; -.
DR HOGENOM; CLU_046525_0_1_9; -.
DR Proteomes; UP000003133; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006036; K_uptake_TrkA.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR43833; POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED; 1.
DR PANTHER; PTHR43833:SF5; TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKA; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR Pfam; PF02254; TrkA_N; 2.
DR PRINTS; PR00335; KUPTAKETRKA.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
DR PROSITE; PS51201; RCK_N; 2.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:EGC26931.1}.
FT DOMAIN 2..128
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 140..222
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 227..348
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 368..449
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 449 AA; 50180 MW; 6350E82CEFC16A3F CRC64;
MKIIVVGGGK VGTALCRSLV AENHDVILIE QDEAVLNQIT KRYDIIGIAG NGANFKILEQ
ADVSHCDIFI SMTEHDEVNM VSAVLAKRMG AKETVVRVRN PEYSNPYFKE KNILGFSLVV
NPELLTARYI ANIIDFPNAL SVEHFANGRV ALMEFKLKED SNLCQMSISQ FRKKFGNIIV
CAIERKGHLE IPDGDFTLDA GDKIYVTGNR LDIVQFHNMV RPRVVKSLMI IGAGKIAYYL
LNILKNSKIE LKVIESNHER ATFFSQEFPD LYVVHGDGTA KDILLEERAN NFDAIATLTG
VDEENIITSM FLNNLGVQKN ITKVNRTSLL EIIDNQDFAS IVTPKGIAVD TVMHFIRGRY
NAQFSNLEAL HHVANGQIET LQFQIKEENK MTGIPLSQLH LKKDVLIAAI IRQGKAIFPT
GDDNLQVGDK IVVTTLLQNI TQIYDLLAR
//
