ID   F0HJY0_9ACTN            Unreviewed;       981 AA.
AC   F0HJY0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Cyclic diguanylate phosphodiesterase (EAL) domain protein {ECO:0000313|EMBL:EGC90363.1};
GN   ORFNames=HMPREF9404_3589 {ECO:0000313|EMBL:EGC90363.1};
OS   Eggerthella sp. HGA1.
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Eggerthella.
OX   NCBI_TaxID=910311 {ECO:0000313|EMBL:EGC90363.1, ECO:0000313|Proteomes:UP000006450};
RN   [1] {ECO:0000313|EMBL:EGC90363.1, ECO:0000313|Proteomes:UP000006450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGA1 {ECO:0000313|EMBL:EGC90363.1,
RC   ECO:0000313|Proteomes:UP000006450};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Nelson K.E.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGC90363.1}.
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DR   EMBL; AEXR01000007; EGC90363.1; -; Genomic_DNA.
DR   RefSeq; WP_009607763.1; NZ_AEXR01000007.1.
DR   AlphaFoldDB; F0HJY0; -.
DR   GeneID; 69511644; -.
DR   Proteomes; UP000006450; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF84; SIGNALLING PROTEIN WITH EAL DOMAIN; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00497; SBP_bac_3; 2.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00062; PBPb; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        506..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          571..710
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          719..974
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   981 AA;  109355 MW;  18EFB417B08856AC CRC64;
     MMFAWAFVIA FTCTVATTTY PGSSRAFADE FATFGKRVVT VAYFEDGDYM STDEEGRYVG
     YNIEYLNEIA RYADWTYEYV KYPSWEEACA ALEASKVDLL PMVYYTEDRE RRMIFSASSL
     CEISTTLNVR LDDTRYAYED FKTFSGMRVG VIANSQDAEA FAQYSEKNGF SADIVAYSAT
     GDLLRALDEG AVDAIAITYL GTNSRFRTVA QFAPEPLYIA LSPERTDIAD ELDSAMSRLK
     LRDPDFATLL YDRYFGINTD QDPVFTEDEY AYLASAPTLR VAYDSYRAPL SYTDPETGAF
     AGAVALLFED IAQITGLKFE FVAADCHDEA VRLVERGDAD IVYDVDRESD PQAIKSLDTT
     GPYLRDPMAL VAGPNPSGSR VALPSGFSLA ASTAYSSYAE YDIVYCDTPK DCFDAVLEGK
     ADIAFADTHV ANYLLAEPQY ESLSVTTITS FFNSMSIGVS RNADRRLVSI LDRCVQYTAE
     SKMTTWLSQS SLAVHPISPF DFLRQYPVQF MAGIVALLGS VLGVALYVSH VKLRAARRVE
     DFSFTDPLTE GWSLARFRSE VGAQMANARD GAYAIVYLDV KSFKGFNAAF GYATGDRVLL
     DLNGTLAGMK AADERYAHVI ADEFVLLVRW RGWDALLEHF DELDRRFNST ETLTELSHRL
     MLQAGVCIIE RSAETPRIDV QTIIEFVDAA RYARDSIGEA SRSTAALYSA SMKDRDIAER
     ALVAAAHDAL ERGEFTAYYQ PKVEIATNRL VGFEALVRWE SPERGLVPPD EFIPLFERTG
     LVVDLDLQVF RLVCARIREQ LDAGEHPLVI ACNFSRLHMR NDAFPETVKS IVDGFGVPIE
     LLELELTENI VMEDLERAER LCRRLKDLGF RIAIDDFGSG YSSLGTLQNL PIDVLKLDRS
     FLMSSESGER CKAILDGVVS IADKLAVNVV VEGVETRDQA SMLVRMDDRI IAQGFLYSRP
     VPRDVSDAQF AVGFIEPNER P
//