ID F0JB19_NEOCL Unreviewed; 302 AA.
AC F0JB19;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587, ECO:0000256|RuleBase:RU365059};
GN ORFNames=BN1204_069420 {ECO:0000313|EMBL:CEL71285.1}, NCLIV_069420
GN {ECO:0000313|EMBL:CCA30170.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307;
RN [1] {ECO:0000313|EMBL:CCA30170.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CCA30170.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCA30170.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CCA30170.1};
RA Aslett M.;
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CEL71285.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL71285.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; CADU01000303; CCA30170.1; -; Genomic_DNA.
DR EMBL; LN714488; CEL71285.1; -; Genomic_DNA.
DR AlphaFoldDB; F0JB19; -.
DR VEuPathDB; ToxoDB:NCLIV_069420; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17872; GPN3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030228; Gpn3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
FT REGION 188..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 33545 MW; D6AEB3C269A53844 CRC64;
MKFGLLVIGP AGSGKSTFCH YMHQHMEVLR RHCRLVNLDP AAEYFAYEPD IDIRELVTVQ
DVEEELHLGP NGALVYAMEF LQERIDWLES QFADFGEDEL FIIDCPGQIE LYTHLSLMAE
LCNSIQSWGI RLCACCCLDV SFMTDAAKLL GGSLMALSAM VQLELPHINL LTKCDLVDKN
LSLAAAQKRA TGRQRRQRNR TQGREEGSES HSESDDEDED EDASSASRTF GLSALAAWPD
YADEPADAKE AAIDALLSRD PHQIVQQLDV SLTGHVRHAR LLVVYFVSFC LGSSTSVIHP
SG
//
