ID F0LL31_THEBM Unreviewed; 583 AA.
AC F0LL31;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN OrderedLocusNames=TERMP_01964 {ECO:0000313|EMBL:ADT84938.1};
OS Thermococcus barophilus (strain DSM 11836 / MP).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=391623 {ECO:0000313|EMBL:ADT84938.1, ECO:0000313|Proteomes:UP000007478};
RN [1] {ECO:0000313|EMBL:ADT84938.1, ECO:0000313|Proteomes:UP000007478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11836 / MP {ECO:0000313|Proteomes:UP000007478};
RX PubMed=21217005; DOI=10.1128/JB.01490-10;
RA Vannier P., Marteinsson V.T., Fridjonsson O.H., Oger P., Jebbar M.;
RT "Complete genome sequence of the hyperthermophilic, piezophilic,
RT heterotrophic, and carboxydotrophic archaeon Thermococcus barophilus MP.";
RL J. Bacteriol. 193:1481-1482(2011).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP002372; ADT84938.1; -; Genomic_DNA.
DR RefSeq; WP_013468234.1; NC_014804.1.
DR AlphaFoldDB; F0LL31; -.
DR GeneID; 10042279; -.
DR KEGG; tba:TERMP_01964; -.
DR PATRIC; fig|391623.17.peg.1962; -.
DR eggNOG; arCOG00933; Archaea.
DR HOGENOM; CLU_023791_0_0_2; -.
DR OrthoDB; 49555at2157; -.
DR Proteomes; UP000007478; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR034471; GDGT/MA_synthase.
DR InterPro; IPR034474; Methyltransferase_Class_D.
DR InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43306; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43306:SF1; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00385; 7_8-dihydro-6-hydroxymethylpte; 1.
DR SFLD; SFLDG01100; methyltransferase_(Class_D); 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007478};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 133..358
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 583 AA; 68055 MW; CC6065E4AFC4F890 CRC64;
MSETVGEIPS GEKEFDELTK KVRDIIEYPE LSEEEFQKLL KKASKGYGGS LPHKTYSLCP
ETRKVVPAVV WEKNGIVWIT KKCPEGLITD AYYEDVEMYY KFREWKFDEK KLMSFNVENS
GVNCPFDCGL CPRHRSHTNL LNIVLTNRCN LSCWYCFFYA KEGQPIYEPT LEQIRMMLRN
AKRENPIGAT AVQFTGGEPT LREDLIEIIR IAKEEGYDHI QLNTDGIRLA FEPELVKKIR
EAGVNTLYLS YDGMTPQTNW KNHWEIPLIF ENVRKAGGPG IVLVPTTIRN VNDHELGAII
NFGLNHLDIV RGVNFQPISL VGRVPKKERQ RFRITIPGAI KKIEEQTNGA IAKEDWYPIP
IAGHIAKFFE SFAGSKYYMT SHFGCGAATY VFLDDDKVIP ISRFLDVEGF VEFLEEKAEE
LSKWKKLGRL EKLKVGAEIF LKFKSFYDEK YAPKSFDVLD IIKNAFAHGT YDALGQFHYK
TLFLGMMHFM DEYNYDVERV ERCVIHYAMP DGRIVPFCTF NVIPELYRDK VQAQFSYSWE
EWKAMHPDWE YKKDKYVRTR EFVEKMKNSE IYRKTYIDIK QYF
//
