ID F0NSB4_LACHH Unreviewed; 1189 AA.
AC F0NSB4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN OrderedLocusNames=LBHH_0781 {ECO:0000313|EMBL:ADX69993.1};
OS Lactobacillus helveticus (strain H10).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=767462 {ECO:0000313|EMBL:ADX69993.1, ECO:0000313|Proteomes:UP000008640};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H10;
RA Zhang H., Zhao W., Chen Y., Sun Z., Sun T., Meng H.;
RT "Complete genome sequence of Lactobacillus helveticus strain H10.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADX69993.1, ECO:0000313|Proteomes:UP000008640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H10 {ECO:0000313|EMBL:ADX69993.1,
RC ECO:0000313|Proteomes:UP000008640};
RX PubMed=21398542; DOI=10.1128/JB.00166-11;
RA Zhao W., Chen Y., Sun Z., Wang J., Zhou Z., Sun T., Wang L., Chen W.,
RA Zhang H.;
RT "Complete genome sequence of Lactobacillus helveticus H10.";
RL J. Bacteriol. 193:2666-2667(2011).
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. {ECO:0000256|HAMAP-
CC Rule:MF_01894}.
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DR EMBL; CP002429; ADX69993.1; -; Genomic_DNA.
DR RefSeq; WP_014563403.1; NC_017467.1.
DR AlphaFoldDB; F0NSB4; -.
DR KEGG; lhl:LBHH_0781; -.
DR PATRIC; fig|767462.3.peg.873; -.
DR HOGENOM; CLU_001042_2_2_9; -.
DR Proteomes; UP000008640; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 2.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 2.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Cell cycle {ECO:0000313|EMBL:ADX69993.1};
KW Cell division {ECO:0000313|EMBL:ADX69993.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01894}; Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894}.
FT DOMAIN 515..636
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 440..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..201
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 255..366
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 677..900
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1189 AA; 134454 MW; 5AB20F8E10649D9C CRC64;
MPLTELVLDG FKSFADRTTI HFNDGITGIV GPNGSGKSNI TEAIRWVMGE ASAKSLRGMN
MKDVIFAGSQ YRKPLNKAEV TLIFDNQKRE LAFDADEVSI TRKILRSGDS EFLINGQQVR
MRDVRTLFLD SGISQNSLAI ISQGRVDQIL NSRPEQRRVI FEEAAGVLHF KQQKEAAQGQ
LKKTQDNLIR INDLVKELEG RLEPLHEQSS LAKEYKFQKA GLDKESKSLL AFEIEDINKQ
KEDVQKSADK NKILLSKLDA EVKESQDAVS KKRAEYQEIR DEREKVQNEL LKLGQQLSDL
NANLQMAEQS RQFDDATKIE YQNQVETLKK SLVELNAHLD NLQKDQANLK KQQAVLQKKR
DKLTGELSEN PEELNKKLED CRNDYIQLLQ DQAAVNNQVI NLNTELKRSK ADTTYQSNDV
AKQLTEAKAE LEKLRTEGKN LTAKRKDKNT AFAETNDQSK ELNEQIRRLQ ETVNDERNKL
EKIEARHEAL INIQKRHEGY YYGVRNVLNH LSDFPGVIGA VGELLTFPAE LEAAMTTALG
GGVQDLITDS RNSAKNAINQ LKRSRAGRAT FLPLDGLRQY TIPQSTVTTL KSFNGFKGIA
SDLVESKTDH NITAAINYLL GSVVIVDSIE NAMAISQRIG RYRIVTLDGD VVSPGGSMTG
GQKNLRNNSP LQTATEINQL EQQIKSLTSS FKEDQAQLKA LVDQSVEVDK KLQELHDSLQ
EINQTINETA ISFQNQEKEV KRLQDANTLY ESRVKERNDH IVELQKQIAD ANDKQTLLSK
QGEEKKSRMN ELQSRIKNFN NLSKRVQSEL SKLDPQIAVF ANKLENLTVQ EKDKRNQIDN
NQKQAADLKE KLASLNQNGE LSVKKNADLK NQKTKIKQKH EELQNRLNEL SLQLGQFDAQ
INQLDQVASR NYDLRKDAAI EQEDYSVKIA KFNSLIDQRL ETLRDDYALT FEAAIAQAEG
KNDQETRDKL AKSVKLHRMS IEDIGPVNLD SIQEYEDVKK RYDFLNGQQN DLLKARDDLE
KSMNELDEEV KSRFKATFEA VAESFKKIFP LVFGGGKAKL ELTEPNNLLE TGIEIIAQPP
GKKLQRLSLL SGGERALTAI TLLFAMLQVN PVPFCLLDEV EAALDDANVT RFAQFLLKYD
LKTQFIVITH RRGTMKQADQ LYGVVMQESG VSQVLSVSLK EMKNKNGVK
//
