ID F0NX81_LACHH Unreviewed; 341 AA.
AC F0NX81;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN OrderedLocusNames=LBHH_p0023 {ECO:0000313|EMBL:ADX71220.1};
OS Lactobacillus helveticus (strain H10).
OG Plasmid pH10 {ECO:0000313|EMBL:ADX71220.1,
OG ECO:0000313|Proteomes:UP000008640}.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=767462 {ECO:0000313|EMBL:ADX71220.1, ECO:0000313|Proteomes:UP000008640};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H10;
RA Zhang H., Zhao W., Chen Y., Sun Z., Sun T., Meng H.;
RT "Complete genome sequence of Lactobacillus helveticus strain H10.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADX71220.1, ECO:0000313|Proteomes:UP000008640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H10 {ECO:0000313|Proteomes:UP000008640};
RC PLASMID=pH10 {ECO:0000313|EMBL:ADX71220.1,
RC ECO:0000313|Proteomes:UP000008640};
RX PubMed=21398542; DOI=10.1128/JB.00166-11;
RA Zhao W., Chen Y., Sun Z., Wang J., Zhou Z., Sun T., Wang L., Chen W.,
RA Zhang H.;
RT "Complete genome sequence of Lactobacillus helveticus H10.";
RL J. Bacteriol. 193:2666-2667(2011).
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594, ECO:0000256|RuleBase:RU362026}.
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DR EMBL; CP002430; ADX71220.1; -; Genomic_DNA.
DR RefSeq; WP_014564429.1; NC_017468.1.
DR AlphaFoldDB; F0NX81; -.
DR REBASE; 33028; M.LheORF23P.
DR KEGG; lhl:LBHH_p0023; -.
DR PATRIC; fig|767462.3.peg.2325; -.
DR HOGENOM; CLU_024927_8_0_9; -.
DR Proteomes; UP000008640; Plasmid pH10.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ADX71220.1}; Plasmid {ECO:0000313|EMBL:ADX71220.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADX71220.1}.
FT DOMAIN 46..328
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 341 AA; 39329 MW; 98D1CF555D260593 CRC64;
MMNTNKVYNN ILSNFNTDTL YRPQKDAAIV EGDSLELMKK IPSHSISLIL TDPPYHSTNK
KNITGDTKFK KDEDFLDWME QFAKEWKRIL KFNGSIYCFC SSQMEYQLIN RFSKDFNILS
TITWTKPNKP GFDGWRKKMK KENLRQWYPA SERIVFMAPK YGENLFNSYF GAKLRSWRNL
VKISGHDLTE ITGAYGKVNH GGAVSNWEAG RNIPSREQYT KIINALKIRD TNGLISFPDY
EDIIRPFNVD GTMQYTDIWD FETVRQYRGK HPAEKPIDLL ENAIKASSYV NDIVLDTFSG
SGSTAEAALS LGRKSISMEI EDKWVQASVD RLKSTQIELK V
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