ID F0P0Y1_WEEVC Unreviewed; 602 AA.
AC F0P0Y1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase., Long-chain-3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ADX68565.1};
DE EC=1.1.1.211 {ECO:0000313|EMBL:ADX68565.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:ADX68565.1};
GN OrderedLocusNames=Weevi_1877 {ECO:0000313|EMBL:ADX68565.1};
OS Weeksella virosa (strain ATCC 43766 / DSM 16922 / JCM 21250 / CCUG 30538 /
OS CDC 9751 / IAM 14551 / NBRC 16016 / NCTC 11634 / CL345/78).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Weeksella.
OX NCBI_TaxID=865938 {ECO:0000313|EMBL:ADX68565.1, ECO:0000313|Proteomes:UP000008641};
RN [1] {ECO:0000313|EMBL:ADX68565.1, ECO:0000313|Proteomes:UP000008641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43766 / DSM 16922 / JCM 21250 / NBRC 16016 / NCTC 11634 /
RC CL345/78 {ECO:0000313|Proteomes:UP000008641};
RX PubMed=21475590;
RA Lang E., Teshima H., Lucas S., Lapidus A., Hammon N., Deshpande S.,
RA Nolan M., Cheng J.F., Pitluck S., Liolios K., Pagani I., Mikhailova N.,
RA Ivanova N., Mavromatis K., Pati A., Tapia R., Han C., Goodwin L., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brambilla E.M., Kopitz M., Rohde M., Goker M., Tindall B.J., Detter J.C.,
RA Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Weeksella virosa type strain (9751).";
RL Stand. Genomic Sci. 4:81-90(2011).
RN [2] {ECO:0000313|Proteomes:UP000008641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43766 / DSM 16922 / JCM 21250 / NBRC 16016 / NCTC 11634 /
RC CL345/78 {ECO:0000313|Proteomes:UP000008641};
RX DOI=10.4056/sigs.1603927;
RA Lang E., Teshima H., Lucas S., Lapidus A., Hammon N., Deshpande S.,
RA Nolan M., Cheng J., Pitluck S., Liolios K., Pagani I., Mikhailova N.,
RA Ivanova N., Mavromatis K., Pati A., Tapia R., Han C., Goodwin L., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Brambilla E.,
RA Kopitz M., Rohde M., Goker M., Tindall B., Detter J., Woyke T., Bristow J.,
RA Eisen J., Markowitz V., Hugenholtz P., Klenk H., Kyrpides N.;
RT "Complete genome sequence of Weeksella virosa type strain (9751T).";
RL Stand. Genomic Sci. 4:81-90(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
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DR EMBL; CP002455; ADX68565.1; -; Genomic_DNA.
DR RefSeq; WP_013598954.1; NC_015144.1.
DR AlphaFoldDB; F0P0Y1; -.
DR STRING; 865938.Weevi_1877; -.
DR KEGG; wvi:Weevi_1877; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_21_1_10; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000008641; Chromosome.
DR GO; GO:0016509; F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43561; -; 1.
DR PANTHER; PTHR43561:SF3; HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Oxidoreductase {ECO:0000313|EMBL:ADX68565.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008641}.
FT DOMAIN 7..187
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..287
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 312..490
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 495..589
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT COILED 34..72
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 602 AA; 67729 MW; A43F2DE6E43DF645 CRC64;
MVGNIKNVTV AGSGVLGYQI AFQTAFHGFH VTVYDISEEI LDKAKAKFEE LAKNFRADLQ
ATDEQIKTAK ENIEYSSDLR KAIENADLLI ESIPENIQIK TEFYQQLAKI APEKTIFVSN
SSTLLPSQFA AYTGRPEKFL NLHFANRIWL HNTAEIMSHS TTQEEVRKEI EQFAKNIGMV
PIVVRKEVPG YVLNSMLSPF LSAALQLWLG QFTTAEYIDK AWMKGTGAPT GPMALYDIIG
LTTPYNIYKL QVEQGKKDDQ KVVDILEKTF IKPNKLGVST GEGFYTYPNA AWQQEDFLAV
PKADLSKIKI KKVVIAGSGI LGLQIAAQAA FYGFDTVIYD LKEEALKEAQ TRFEPLLLEY
QKYLQANEKQ IEQTRLNLEF SHDLEKALQD ADLLIESIPE SLEIKESFWI EVSKYAPEKT
IFASNSSTLL PSRIKDFTGR ADRYIHLHFA NHILVRNIAE IMGSSDTSPE IFTKMVEFAK
AINMLPIELK KERAGYVLNS LLVPLLVAGL SLWANDVADP ETIDKTWMIA TGAPIGPMAI
LDITGMNTNY NVLKNNPAEF MHKLAHKLKI EFIDKGNLGQ QSGKGFYEYP NPAWQQENFL
KA
//
