UniProt: F0T6M9

Database: UniProt
Entry: F0T6M9_METLA

LinkDB:  F0T6M9_METLA 
Original site:  F0T6M9_METLA

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (19)   
   InterPro (13)   
   Pfam (3)   
   PROSITE (3)   
Literature (1)   
   PubMed (1)   
All databases (30)   

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ID   F0T6M9_METLA            Unreviewed;       811 AA.
AC   F0T6M9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Heavy metal translocating P-type ATPase {ECO:0000313|EMBL:ADZ08262.1};
DE            EC=3.6.3.4 {ECO:0000313|EMBL:ADZ08262.1};
GN   OrderedLocusNames=Metbo_0009 {ECO:0000313|EMBL:ADZ08262.1};
OS   Methanobacterium lacus (strain AL-21).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobacterium.
OX   NCBI_TaxID=877455 {ECO:0000313|EMBL:ADZ08262.1, ECO:0000313|Proteomes:UP000007490};
RN   [1] {ECO:0000313|Proteomes:UP000007490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AL-21 {ECO:0000313|Proteomes:UP000007490};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Cadillo-Quiroz H.,
RA   Imachi H., Zinder S., Liu W., Woyke T.;
RT   "Complete sequence of Methanobacterium sp. AL-21.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADZ08262.1, ECO:0000313|Proteomes:UP000007490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AL-21 {ECO:0000313|EMBL:ADZ08262.1,
RC   ECO:0000313|Proteomes:UP000007490};
RX   PubMed=24449792; DOI=10.1099/ijs.0.059964-0;
RA   Cadillo-Quiroz H., Brauer S.L., Goodson N., Yavitt J.B., Zinder S.H.;
RT   "Methanobacterium paludis sp. nov. and a novel strain of Methanobacterium
RT   lacus isolated from northern peatlands.";
RL   Int. J. Syst. Evol. Microbiol. 64:1473-1480(2014).
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DR   EMBL; CP002551; ADZ08262.1; -; Genomic_DNA.
DR   RefSeq; WP_013643613.1; NC_015216.1.
DR   AlphaFoldDB; F0T6M9; -.
DR   STRING; 877455.Metbo_0009; -.
DR   GeneID; 10276431; -.
DR   KEGG; mel:Metbo_0009; -.
DR   eggNOG; arCOG01576; Archaea.
DR   eggNOG; arCOG02763; Archaea.
DR   eggNOG; arCOG02764; Archaea.
DR   HOGENOM; CLU_001771_0_3_2; -.
DR   OrthoDB; 8588at2157; -.
DR   Proteomes; UP000007490; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   CDD; cd00371; HMA; 2.
DR   CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR   Gene3D; 3.30.70.100; -; 2.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006122; HMA_Cu_ion-bd.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR   NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 1.
DR   NCBIfam; TIGR00003; copper ion binding protein; 2.
DR   PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR   PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00403; HMA; 2.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00942; CUATPASEI.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 2.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS01047; HMA_1; 1.
DR   PROSITE; PS50846; HMA_2; 2.
PE   4: Predicted;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Hydrolase {ECO:0000313|EMBL:ADZ08262.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007490};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT   TRANSMEM        167..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        434..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        749..773
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        779..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..73
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          75..141
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
SQ   SEQUENCE   811 AA;  87148 MW;  4E3043E07AA47FF1 CRC64;
     MVNQPKKNAN IKISGMGCAS CALNIEKSLN ELEGVETATV NLGTEEASVN YDPKKLQLAD
     LTEAVEEAGY EVVNDKITIK VGSMSCAMCV KAIEDGLNKL DGVSDVNVNL ASEKAYITYN
     PAMVGVKEFK NTIVDLGYDY LGVEGEETQN LEEELIERDL KGKRNRIIVA FGFAIPIMIL
     MFSNITTPIP MTYLFLIISI LPFIYVSYPI FSAAYRSLKN GNLDMDVMYS MGIGVAYVSS
     VLGTFSILLT PEFMFYETAL MLAGFLMLGR YLETRAKGRT STAIKKLAGM QAKTATVMRE
     GEEVLISVED VEIGDTVVVK PGEKIPADGV VCSGESYVDE SAITGEPIPV LKNKGKDIVG
     GTINKNGTLN FKTTKVGKDT VLAQIVKLVE TAQGSKPPVQ KIADKAVTYF IPTVLTIAIV
     AFIVWYLLLG SSLLFGLTVL ISILVVACPC ALGLATPTAI TVGLGKGAEL GILIKNGDAL
     EISEKLTTIL FDKTGTLTRG KPEVTDIISF ELDKNELLFY AATVESRSEH PLADAIVRKA
     RAENLSLGEV EEFDSFGGKG VKAVVNAKNI IIGNRSLLRE KNIELNSENE ANIFKIEKDG
     KTVILVGIDD VLAGLIAIAD TIKPNTANAI AELKKMDLKI TMITGDNERT AKAIASQVGI
     YNVISEVLPQ DKSAEVKRLQ DAGETVSFVG DGINDAPALA QADVGIALGS GTDVAIESGD
     IVLIKDDIMD SVAGIQLSKK VISRVKQNLF WAFAYNVVLI PVAAGILYAP FGILFRPEYA
     GFTMALSSVT VVSLSLMLKS YLPPAKKLEK I
//

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