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Database: UniProt
Entry: F0T8R3_METLA
LinkDB: F0T8R3_METLA
Original site: F0T8R3_METLA 
ID   F0T8R3_METLA            Unreviewed;       550 AA.
AC   F0T8R3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   25-OCT-2017, entry version 28.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   OrderedLocusNames=Metbo_0353 {ECO:0000313|EMBL:ADZ08605.1};
OS   Methanobacterium lacus (strain AL-21).
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanobacterium.
OX   NCBI_TaxID=877455 {ECO:0000313|EMBL:ADZ08605.1, ECO:0000313|Proteomes:UP000007490};
RN   [1] {ECO:0000313|Proteomes:UP000007490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AL-21 {ECO:0000313|Proteomes:UP000007490};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I.,
RA   Cadillo-Quiroz H., Imachi H., Zinder S., Liu W., Woyke T.;
RT   "Complete sequence of Methanobacterium sp. AL-21.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP002551; ADZ08605.1; -; Genomic_DNA.
DR   RefSeq; WP_013643956.1; NC_015216.1.
DR   EnsemblBacteria; ADZ08605; ADZ08605; Metbo_0353.
DR   GeneID; 10276790; -.
DR   KEGG; mel:Metbo_0353; -.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000007490; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007490};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000007490};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:ADZ08605.1}.
FT   DOMAIN        3    268       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      316    441       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       147    147       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     257    257       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     271    271       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   550 AA;  60359 MW;  4D976CC6EAAC6EBA CRC64;
     MAEKMFIDAL KKAFKEDPTD DKTTFYNKGG WKQSERKREF VAAGKDIAAK RGIPMYDPDV
     GTPLGQRVLM PYQVSTTDTF VEGDDLHFVN NAAMQQFWDD IRRTVIVGMN TAHMVIEKRL
     GKEVSPETIT NYLETVNHAM PGAAVVQEHM VETNPYLVAD SYVKTFTGND EIADEIDPAY
     VLNINKMFNE EQAEVLKAEV GDGIWQVVRI PTIVSRTCDG GTTSRWSAMQ IGMSMISAYK
     QAAGEAATGD FAYAAKHAEV VHMGTALPQR RARGENEPGG IPFGYLADIC QSSRVNPEDP
     AKVTLDVVAS GAMLYDQIWL GSYMSGGVGF TQYATAAYTD NILDDFVYYG KEYVEDKFGM
     TEAPNNMDTV LDVGSEVTFY ALEQFEEYPA LLETIFGGSQ RASIVAAAAG ASTGFATGNA
     QTGLSAWYLS MYLHKEQHSR LGFYGYDLQD QCGASNVFSI RNDEGLPVEM RGPNYPNYAM
     NVGHQGEYAG IAQSAHAARG DAFVFNPLVK IAFADDNLAF DFSNVRAEFA KGALREFEPA
     GERALISPAK
//
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