ID F0U6A8_AJEC8 Unreviewed; 1001 AA.
AC F0U6A8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=SMC (Structural maintenance of chromosomes) domain-containing protein {ECO:0000313|EMBL:QSS52128.1};
GN ORFNames=HCEG_00806 {ECO:0000313|EMBL:EGC41444.1}, I7I53_07646
GN {ECO:0000313|EMBL:QSS52128.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|EMBL:EGC41444.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC41444.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS52128.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS52128.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS990636; EGC41444.1; -; Genomic_DNA.
DR EMBL; CP069103; QSS52128.1; -; Genomic_DNA.
DR AlphaFoldDB; F0U6A8; -.
DR STRING; 544711.F0U6A8; -.
DR VEuPathDB; FungiDB:I7I53_07646; -.
DR HOGENOM; CLU_004834_0_0_1; -.
DR OMA; MKSDQIY; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR InterPro; IPR025925; PPC89_CLD.
DR PANTHER; PTHR19336:SF9; SPINDLE POLE BODY PROTEIN PPC89; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14197; Cep57_CLD_2; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 415..479
FT /note="PPC89 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14197"
FT DOMAIN 835..911
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 1..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 345..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 412..481
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 112392 MW; DD96926328E56878 CRC64;
MSPVDHTNTS DVMADSHASR DLTTSDFDPD HEALVSARQL DNSHGQRLPN RAKPRDVQAD
PEAEPDFAID TSALHRAFPD FSDTSSSEEE DDISIEMGRG GKKPLQRLDD SRDSVMSVDD
SRYSASPVVR GDRFSNSPHR AALRPIPNRG LSSRDSLRKD AQIRRASLAL KNNNLPQDAR
NKSGSQRRTL SEMHAKASEA YDGSYVSDER PANITSTTRN TRFGNMRQGV KVVDAVNKAA
GKPYLKHHDA DVDRGELRRQ PAAKTAENNA TADNLTHQSF ALPDIPNLSD LVSGIYEDGT
PKGRSRTTRF TSPPVVGTAH RQRHEYFPLD SIPVPDDEKA IFISLKLLQE KLEALQMDKS
DMERRLEEIE EENMILKSEN TRWQKQDKNL RMYGGDEDIN DGRRNGNHSI QRSRLEAANS
ALQNRLDIFT RKISSHETRI QHLIQERDSA RTQLGVAYLN LQELKMENDV LGQENDELKI
QLESLTEYPE ATHGKQHKQT HDSKTIGRGI ATRDQIETTE TNRTRLARGV ESLDADASVR
KNAVDAQRQN SHNIHTRQQK QTEYDELFSL DLSHLSVQQH TRHTKTRANT TEKKLPNTSK
QRTKKPIIEY SEDIELSEGE MGTEIRGFRY RNGPANDLTF LSFIDANEIA QLRKTLEEER
VARNNRLNRD FTEQSKISNL TLRTSGNFKQ SAPLKSLLKN AVSRDGRTVT VEVPGVDITE
QGAAANTTRD LSQRIDTRRR QKRTEEMTSA FILPDITMHV VTAKPGEPLK LSEAAQRVLD
DVAQHDGKNC SVCKSVMNKN STHDHSGEGH DSIKVSKPIP VSDRMPDPSP YNEEPTLRPS
QPPAVALAAV LKLLEDELAH LKMRLALQQT ALNKHDASLG KKQRKSILHK IEAILREIDM
KSDQIYALYD VLEGQKENSH EMTQDEVDVT LQSIGLGRVT GKGASDYTDR LGRNDPKDKD
ATRAHDSEGD SDYDELPWEG FESTGDVTGR SFSRKAGKSS S
//
