ID F0UB11_AJEC8 Unreviewed; 682 AA.
AC F0UB11;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Puf family RNA-binding protein {ECO:0000313|EMBL:EGC42974.1};
GN Name=PUF6 {ECO:0000313|EMBL:QSS49162.1};
GN ORFNames=HCEG_02189 {ECO:0000313|EMBL:EGC42974.1}, I7I53_09446
GN {ECO:0000313|EMBL:QSS49162.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGC42974.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:EGC42974.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS49162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS49162.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit. {ECO:0000256|ARBA:ARBA00024893}.
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DR EMBL; DS990637; EGC42974.1; -; Genomic_DNA.
DR EMBL; CP069102; QSS49162.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UB11; -.
DR STRING; 544711.F0UB11; -.
DR VEuPathDB; FungiDB:I7I53_09446; -.
DR HOGENOM; CLU_013994_1_0_1; -.
DR OMA; YGPEFSI; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 1.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012959; CPL_dom.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR040059; PUM3.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13389:SF0; PUMILIO HOMOLOG 3; 1.
DR PANTHER; PTHR13389; UNCHARACTERIZED; 1.
DR Pfam; PF08144; CPL; 1.
DR SMART; SM00025; Pumilio; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008142};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 140..546
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 75690 MW; 9BFA491B68B6D6FF CRC64;
MAGIKRRFDT ADGRDGKRTK VKDGGRVNKN KPVVESKSKS KKPQRKVESS EDDEEEEDFN
FSEEGVDVDD SPSDSEDTTQ HQKSKTRSES LSSSEKQANG TGGGALSVKS GTSSKESHAK
QKALAQERKA AKPNSDLIAR SKKLWERLRR KSHVPLEERK KLVAELYSIV TGRVKEFVFK
HDSVRVIQTA LKYASPQQRK DIAKELKGNY CSLAESKYAK FLIGKLLVHG DSEVRDIIIP
EFYGHVKRLM RHPEASWIVD DIYRTVATAT QRAMLLCEWY GAEFVVFRPA DGVPETADLA
EIISKNPEKR GPIMKYLHEF INHLVQKKFT GFTMLHDAML QYFLNTTPGS EEAAELVQLI
LGDEEGDLAK NLAFTKSGAR LVSLCFAYSN AKDRKLLLRL YRGTMKMLAG DVNGQVVLLT
AYEVIDDTKL SSKSIFPELL NQASTAEARH EELLLQITDL TARIPILYSF AEDTTRWLVT
DPDHKKILDE VLAVRSQTSK KDPNTRRQEL VKAASPTLLE FIAASADSLV EYSFGCQFIT
EVLFSADGDK TAALTAIAAL PTSKSEALKN PSAGRMLKAL VQGGRFNSKT KCVEKVQPPL
NFHGLLYEQI AANVMAWVTG ANPFVILALV EAEDFGKRGE LVKTLTKHKK VLAELSAKEP
ANKGVKRGAV SSAAKLLLER VG
//
