ID F0UIR7_AJEC8 Unreviewed; 1051 AA.
AC F0UIR7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Zinc metalloprotease {ECO:0000313|EMBL:EGC45620.1};
GN ORFNames=HCEG_04835 {ECO:0000313|EMBL:EGC45620.1}, I7I53_04440
GN {ECO:0000313|EMBL:QSS56270.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGC45620.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC45620.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS56270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS56270.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS990639; EGC45620.1; -; Genomic_DNA.
DR EMBL; CP069106; QSS56270.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UIR7; -.
DR STRING; 544711.F0UIR7; -.
DR VEuPathDB; FungiDB:I7I53_04440; -.
DR HOGENOM; CLU_006065_0_0_1; -.
DR OMA; YITEVHH; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 5.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43016:SF16; METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED; 1.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EGC45620.1};
KW Metalloprotease {ECO:0000313|EMBL:EGC45620.1};
KW Protease {ECO:0000313|EMBL:EGC45620.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 61..137
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 198..383
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1014..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1051
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 119189 MW; 514E40ED86EE90CB CRC64;
MSSPEKRNYF QVLQRFKPDY SPNYFTQYES ERTGMKVVVI DQKGPKVSGY FVLATEILDD
SGAPHTLEHL CFMGSRNYQY KGFLDKLATR AYSHTNAWTS TDHTAYTLYT AGWAGFAQIL
PVYLEHIIDP TLTDAGCYTE VYHVDGTGND AGVVYSEMQG VQNKSSELID LKCRRLLYPE
GIGFRYETGG MMEQLRVLTA ERIRAFHRKM YQPKNLCLII TGEVDHDNML QILNVFESTV
LDVIPSPNDP FRRPWMESQP IPPLERSIVE KVEFPEADES FGEIEIRFLG PDCSDTLLSD
ALDVVLLYLA GSSATILENT LVEKEHLTSA VYYSTSQTPR TEISFTLTSV ATEKLEQVER
RFFEVLKEAM QNEIDVEYMQ ECVRRQRRSW KFSTESSVSP FAHYVICDFL FGKRDGSTLR
HVASLHEYDE LEKWHDHQWR AFIKQWISDA PHVSILGVPS SKLATKLKED EQSRIAERKR
ALGEEGLKKL AEKLEEAKAA NDKPIPQGEL TKFEIPGVES IPFIKTTTAK SGLALSTGRP
NNRIQQLVDA DAPDSPLFIH FEHVASNFIQ IFLNISTTSV PAELRPLLAV YMQAYFNLPV
LRNGEKVPFE QVIVELERDT VSYNMDIGHH NPEMLIISFQ AEPDKYDAII SYITELSWES
IFDVERLKAI TTRLLSDVPD AKRNGSRMVD AVQTMVSHTQ ESIVRAMAPL TRALYLKCTK
RQLEQNPEVV VARMEIIRKQ LFRFENFRIF VIADMDKLRN PSSAWGPFVS RLDVTQPLSL
IIQLRDRLKD VAKNPGTMAH LVPMTTIDSS FVLTSAKGLD SYNHPKLPAL LVTIAYMNAV
EGPLWVAIRG TGLAYGSRFL HDVDTGLLQF QVYRSPNVYR AFEEGKKIVE NHLSGAEQFD
PHMALEGAIS SIVLDFVNEE TTQASTALAS FVRQVIRGLP SDYQEKLLRK VREIGIEEIK
EILRDFILPL FTPGKSDIII ACGRVLEGPI KKGFEGVGYK PEVRSLKFFE DDYGLKLEGG
EDDEDEDGDE DEEAEESGSD DSMDNDDEMA N
//
