ID F0UKW7_AJEC8 Unreviewed; 663 AA.
AC F0UKW7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Vacuolar sorting protein {ECO:0000313|EMBL:EGC46071.1};
DE SubName: Full=Vacuolar sorting-associated protein {ECO:0000313|EMBL:QSS56699.1};
GN Name=VPS33 {ECO:0000313|EMBL:QSS56699.1};
GN ORFNames=HCEG_05286 {ECO:0000313|EMBL:EGC46071.1}, I7I53_04984
GN {ECO:0000313|EMBL:QSS56699.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|EMBL:EGC46071.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC46071.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS56699.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS56699.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC {ECO:0000256|ARBA:ARBA00009884}.
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DR EMBL; DS990639; EGC46071.1; -; Genomic_DNA.
DR EMBL; CP069106; QSS56699.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UKW7; -.
DR STRING; 544711.F0UKW7; -.
DR VEuPathDB; FungiDB:I7I53_04984; -.
DR HOGENOM; CLU_016678_3_1_1; -.
DR OMA; FHIFFVP; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.850; -; 1.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR InterPro; IPR043155; VPS33_dom3b.
DR PANTHER; PTHR11679:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33B; 1.
DR PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR Pfam; PF00995; Sec1; 1.
DR SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 663 AA; 73249 MW; F8FDE5B20FB28710 CRC64;
MAPDPGSEAE YIREKARRDL LNLLEGVRGK KNLVISKDLA GPVGLFVKFS VLQEYGVDRV
FLLENGNTDS SQKNIVFLVH AEKPAQVQST AEQIKKLQRN GTVEHEFSIF WVPRRTLVCN
QILEDEGIIG DVNITEFPLY FLPLESDILS LELGDAFPDL YLHKDPGPVY LSAKALMNLQ
LRHGFFPRIV GKGDNARRLA DQLLRMRKEL DVEETSGLND GSGRGLMVSS TIESLIVIDR
DVDFATPLLT QLTYEGLVDE FFEIANNQTE VDSMVIGPSA LTPSSSQVAS SGTSSAAAKQ
GLKRKIQLDS SDQLFGQLRN ANFAIVGGLL NKVARRLESD YESRHVAKST SELREFVNRL
PAYQAEHTSL KVHTNMAEEI MRQTLSDVFR KALEVQQNIA AGSDPTYQHR IIEELIARDV
PLNTVLRLLC LESCMNGGLR PRDLENFRKQ ILQAYGYQHL LTFHALEKME LLQARSSATA
MLLPTGGGQA GLKSNYNHLR KSLRLIVDEV NEQDPDDVAY VYSGYAPLSV RLVQCVLQKP
YIMSLTKGLP ASAAGASANV SSPGWLGFEE IVKSARGSTL NIVQKGDEKA VRARQTLSGT
GGIKTVFVFF LGGITFTEIA ALRFIASKES ARRRIVICTT GIISGNRMLK VAIETKGFTK
SLT
//
