ID F0UPQ1_AJEC8 Unreviewed; 1416 AA.
AC F0UPQ1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=HCEG_06219 {ECO:0000313|EMBL:EGC47004.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; DS990640; EGC47004.1; -; Genomic_DNA.
DR STRING; 544711.F0UPQ1; -.
DR VEuPathDB; FungiDB:I7I53_00349; -.
DR HOGENOM; CLU_005022_0_0_1; -.
DR OMA; FEADEKC; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025337; Questin_oxidase-like.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF14027; Questin_oxidase; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EGC47004.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EGC47004.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:EGC47004.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 304..466
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 520..691
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 201..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1416 AA; 159191 MW; 0DC7D9E7FB0FF579 CRC64;
MPPKRKAAGK VVEKFSLQAF SQKKKADIQR QDPHFGYKDF SSLPLKPDHA NRPLWIEPLK
GTITLESFSP LAPQAQDFLT TIAEPLSRPT HLHEYRLTGN SLYAAVSVGL LPGDIINFLD
RLSKTPLPET IKSFIVNFTK SYGKIKVVLK YNRFFVESSD PATLQMLLQD EVIGPQRLQN
SEGIIQQAAP KMAGLVIPGT KDAAGVKQNP DRKPMEGDTN GRPKEDGLLV DLREEDDDDD
PAQVHSFEIP NTAVESVKAR CQSMGCPALE EYDFRNDEIN PTLDIDLKPN AQIRSYQEKS
LSKMFGNGRA KSGIIVLPCG AGKTLVGITA ACTIKKGTII LCTSSMSVVQ WRNEFLRWSN
IDPSDIAVFT SDNKEKFRRN TGIIVSTYSM VSQTRARSHD AEKMMDWMQS REWGLMILDE
VHVVPASMFR KVTSAIATQT KLGLTATLLR EDDKIKDLNF LIGPKLYEAN WMELAEQGHI
AKVQCAEVWC PMTTEFYTEY MREKSRKAAL LYIMNPRKFQ ACQFLIDYHE KRGDKVIVFS
DNVYALERYA LKLNKAYIYG GTPQNERLRI LENFQHNEQV NTIFLSKIGD TSLDLPEATC
LIQISSHYGS RRQEAQRLGR ILRAKRRNDE GFNAFFYSLV SKDTDEMFYS SKRQAFLVDQ
GYAFKVITHL EGIENLEGLA YATPTERREL LQEVMLQNET SAAVEEVVDD LFSERSGGPK
ARGAAKKVAV KRSAATLSGL AGGEDMAYIE YNKSRNKQLK EKVGHHPLFK KIERDRLKRK
KALGLDKKFL TTAPVCLLGS MMGCQGMNPM NIRDMTRFIL PADVCLLIEH KSRTSHSLSS
SSCEVPSDGA MTEWLARVLV STTPPHRSLC GSRGSYGEAA ERERGGLIHY LPMTSVAQRY
RHQVARCMLC CAHIPARAFR RAQQGTVYQD RSLGPGPPKA VTQIAKREPF FSPESKSCFT
PALSKENLKL DLCLRAMATA THIKVSTDDT GILGLRQNAD SAKKVSETLQ ADLERYHIFF
NAKGFHNHLA HHILSAYALG ASADLLQQIF DRAATYQLPS RPVDEAIVQK LGDKAQFSAL
LGIRDQYPNF LVYFQRQIEK RGMEVVVNEY LFAADKLADD MLVRLFAGLI HPFIQLGFGV
EFNQPAIVAE ALAETAVHES NLTFLLPAEE AAGGVGKEGK KSLVHLQQEI RSNTQIREAV
RWKDVNKIDG MLARAPDEII KITSQFSVGP DQLELKLAEL LNAVAYFAGA AQRPQKRVKF
DFFYMHCVTS AIFLASFVSQ PWISKQNKLR ILEWKGRMDL ATYASRGAAE LRQEEITDYE
PKLSWEEVFA QAINHPQDDG HASKFIRTLA FGEKLCKPFE ADEKCREAFL VNGDMWIKLA
NMGEFLQSKF LKTQTLQLAR ASWNFLQSAS CPGFII
//
