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Database: UniProt
Entry: F0UQF1_AJEC8
LinkDB: F0UQF1_AJEC8
Original site: F0UQF1_AJEC8 
ID   F0UQF1_AJEC8            Unreviewed;       567 AA.
AC   F0UQF1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:EGC47941.1};
GN   ORFNames=HCEG_07156 {ECO:0000313|EMBL:EGC47941.1};
OS   Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS   capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN   [1] {ECO:0000313|Proteomes:UP000008142}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA   Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA   Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA   Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA   McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT   "Annotation of Ajellomyces capsulatus strain H88.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790}.
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DR   EMBL; DS990640; EGC47941.1; -; Genomic_DNA.
DR   AlphaFoldDB; F0UQF1; -.
DR   STRING; 544711.F0UQF1; -.
DR   VEuPathDB; FungiDB:I7I53_10045; -.
DR   HOGENOM; CLU_002865_6_1_1; -.
DR   OMA; EHAMGNA; -.
DR   Proteomes; UP000008142; Unassembled WGS sequence.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF115; DEHYDROGENASE XPTC-RELATED; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT   DOMAIN          249..263
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00624"
FT   ACT_SITE        501
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT   ACT_SITE        544
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT   BINDING         210
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ   SEQUENCE   567 AA;  61979 MW;  C51FDDC4E3D86C49 CRC64;
     MLLSFLPSGS RARTLCYALI LFASFATSSV LVRDGDKQSL RDRNEFDYII VGGGLTGLVA
     AHRLSENLFG MAYDRASAAD YDSWEALGNR GWGWKGMFPY FRKSADFTPP KKAVVNKYGY
     TYDESAYGRF GPLQVTFPDW QVPDQYKMAG AFTELGVAHL REHAMGNAVG QFWAPATIDA
     KTMTRSSSLT AYYDKASWRP NLKMLTEHKV TQLTFKGAST TVSGVKAINR KTNKEVTFRA
     RKEVILAAGS LHTPQILQLS GIGPKCVVEA AGIKSRVDLP GVGSNLQDHP VAYLNWKVTN
     SFPEPNIMTT NETFAAEALA EYQAHRTGPY TKAQSNTIAF LSLPMVTNNT EDMINSLKQQ
     VASKYLPGVY SRELIAGYEA QRAILAKQLG EGSVSALEFP FGGSGMVPNS VQKPLSRGTV
     HLNPDDPHGE PIVTYNAFTN PFDRAQLASF IAFTRRYFKT NALADMQPQE VSPGEDAQTE
     DEIIAKLAAG GPLSLSPSFA HPSSSCPMMP KNKGGCVGAD LRVHGTRKLS IIDASILPII
     PSAHLQATMY AVAEKASDII KWRSFWP
//
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