ID F0UT75_AJEC8 Unreviewed; 661 AA.
AC F0UT75;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Inner membrane magnesium transporter mrs2 {ECO:0000313|EMBL:EGC49102.1};
GN Name=MRS2 {ECO:0000313|EMBL:QSS54701.1};
GN ORFNames=HCEG_08317 {ECO:0000313|EMBL:EGC49102.1}, I7I53_02342
GN {ECO:0000313|EMBL:QSS54701.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|EMBL:EGC49102.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC49102.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS54701.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS54701.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
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DR EMBL; DS990642; EGC49102.1; -; Genomic_DNA.
DR EMBL; CP069104; QSS54701.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UT75; -.
DR STRING; 544711.F0UT75; -.
DR VEuPathDB; FungiDB:I7I53_02342; -.
DR HOGENOM; CLU_025144_2_1_1; -.
DR OMA; RSNWRAD; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR Gene3D; 2.40.128.330; -; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890:SF26; MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13890; RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 507..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 593..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 73552 MW; DEA9AF884ED37CE3 CRC64;
MVAPSSTLKP SVPSANLLRF LRSQSETSAH HYFFSPNTPP VAHPHSLPPA CPWRFRSQAQ
SQRRYTLSAF QQRSLDEYKH NIQSTVLHNQ PCSATLEASL FPFLTARPGR STDSPSSLSA
ISSVALASAA APRAALNSLN WRGGYGYLQA FSGTAGRKGR GQGFMRRLFG LRVSERDDRR
ELWPSDLPIG PVMEDGHEGN MFVTGRSLAM KAMNEPRLRC TELDENGNVT LVSGEFKKSE
LTAKYGLLPR DLRKIDSSVL PHILVRHSAI LISLLHLRVL IKSDRVLVFD AYGSTDSYTQ
SVFMYDLEGK LRQKEAAGRQ SSPGALPYEF RALEAVLVSV TTGLEAEFEG VREPVVRVLR
ALEEDIDRDK LRRLLIYSKR LGTFEQKARL VRDAIEDLLE ADDDLTAMYL SEKAQGVHRQ
EVDHQEIEML LESYHKVCDE IVQASGNLVT NIRNTEEIVK AILDANRNSL MLLDLKFSIG
TLGLAAGTLC SALYGMNLKN FLEESDIGFT AVSGVCFAFA AFVCAYGLMK LRKVQRVRMW
GEAGLHDRSI GALGLRSDRR AANRTDWRSD FVGPLWTGLA GETRGERLKR LRQRVTASAP
ASVTPPIAKN SHGFEKQHKV QRQRQRLQQQ HQHPQLTDHD GVDTSSAEPE LASTAISSAS
R
//
