ID F0UUQ7_AJEC8 Unreviewed; 1362 AA.
AC F0UUQ7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=p150 dynactin NUDM {ECO:0000313|EMBL:EGC49634.1};
GN ORFNames=HCEG_08849 {ECO:0000313|EMBL:EGC49634.1}, I7I53_11738
GN {ECO:0000313|EMBL:QSS57533.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGC49634.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC49634.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS57533.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS57533.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR EMBL; DS990643; EGC49634.1; -; Genomic_DNA.
DR EMBL; CP069107; QSS57533.1; -; Genomic_DNA.
DR STRING; 544711.F0UUQ7; -.
DR VEuPathDB; FungiDB:I7I53_11738; -.
DR HOGENOM; CLU_002523_1_1_1; -.
DR OMA; LFEMEPV; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 6.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 24..66
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 76..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 293..555
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1086..1113
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 117..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1362 AA; 153230 MW; A00A0314DFD9FF69 CRC64;
MGDLSPGQVV CLSDGRNAII RFIGSTSFAP GDWIGVELGE PTGKNDGSVQ GERYFDCEHG
FGMFVRPAAV VSVLEQPKQE ERKTGPKGGL HGASQRSRPP SGTAGSGLVP KKQSVPGPNA
SRKQSTTSSP SPAPRPGAPG RPLRSPTKSP TKQLSTTSRT STIGPRPPAT ASKPRQSLSG
RNSMAPTPTP VAAKGLRQSL MGTSSKASRP LSQPPRPTFT GPAKRISPRP TASSRTTNIE
KIRSPTSELS EETGDTETSN THSESSKPTS APRVSLAVPQ RSVSGTNPVL KEVEDLKTKL
RVMEKKRVED REKLKSLETL RSERDKFEVI IQKLQTKYQP QQQEITQLRK QLKDAMARVE
EAERLQAEHE SIVEMATLDR EMAEEMCEAI KAEFEALKEK SEELELEVEV LREENQELGQ
VMSPEEKSSQ GWLQMERTNE RLREALIRLR DMTQQQETDL RNQIKELEGE LEDFAAIKAN
YEIAKEQLLI TEANMEDLKQ QVEALGAEDM IEELAEKNMQ YQEQVNELKA VIEDLESLKE
INDELEINHM ETEKQLQEEM DFRETIYLEQ ARRMAQQDEV IEDLEYTLSK FRELVSNLQS
DLEDMRVSQQ LTETESTELT ARSRAMMDLN MKLQASVSKA QTKTIEVELG RMAAEESAQY
LEIMKLYLPE YFESERNPIL ALLRFKRVSF KASLMATSVR ERISDPTSPS AGQDVFAAYE
VLEKLTWIAS LCDRFINFIN GCSTEEFSAF EGAVYELEPV ERILNSRIEG LKKNELDEKK
CAIELQRSIA LLSHLAEALI PPNLESHADR IYMRSVMTQT YLDYAALSLS QLRSTLQARF
PPPSDDDEEG LLLYQKIDAL GNQTRTGKII AGKITRYLDD LKSRCLALTE DCADPFEKCE
GAAKELSELA RQLGENIALL TEEEGRTEPV TYAEITSNMS QTVMSLLQPS SVVAESDDNN
ALSIAASKLR ILRSYLEEAS NASSDLTQTV EFERHPAPWT LRANELKSNK VISPDADEEI
RRLKNEVHET STALGVKDKA FEEQTIKIEL LESRMRDAGK KAALVKELGF KFEALQEKEQ
ELIGIVEKQS ADLQNMERER DDYRARLEKL KRASGSTGVV LGADGVMSID AAASSAVMKE
NEALRAEVAS LQSAVRFLRE DNRRANFMDP YSVQRTNHLR SWLDTPLVRP KIAPEDKRAE
YNAASECQDV LTHLLKLTKE SKFVDLRSTL PPDEASRLSW RPIKSTTRYQ VLRQREEYEQ
WAQWKDDVAR RERLRARKEH KSIKKNSYHL DTTEIPAEIS LAKVSSDSRE AIVLNDSGGQ
ILPTKGRRVM DRAWKILGMQ GDDDSHDESE YGEPGEVKIV NH
//