ID F0V2S3_MYCS3 Unreviewed; 193 AA.
AC F0V2S3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
GN Name=tdk {ECO:0000313|EMBL:CBZ40145.1};
GN ORFNames=MSUIS_00520 {ECO:0000313|EMBL:CBZ40145.1};
OS Mycoplasma suis (strain KI_3806).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=708248 {ECO:0000313|EMBL:CBZ40145.1, ECO:0000313|Proteomes:UP000008645};
RN [1] {ECO:0000313|EMBL:CBZ40145.1, ECO:0000313|Proteomes:UP000008645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KI_3806 {ECO:0000313|Proteomes:UP000008645};
RX PubMed=21398558; DOI=10.1128/JB.00187-11;
RA Oehlerking J., Kube M., Felder K.M., Matter D., Wittenbrink M.M.,
RA Schwarzenbach S., Kramer M.M., Hoelzle K., Hoelzle L.E.;
RT "Complete genome sequence of the hemotrophic Mycoplasma suis strain
RT KI3806.";
RL J. Bacteriol. 193:2369-2370(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC Evidence={ECO:0000256|RuleBase:RU000544};
CC -!- SIMILARITY: Belongs to the thymidine kinase family.
CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR EMBL; FQ790233; CBZ40145.1; -; Genomic_DNA.
DR AlphaFoldDB; F0V2S3; -.
DR KEGG; msk:MSUIS_00520; -.
DR HOGENOM; CLU_064400_3_0_14; -.
DR OrthoDB; 9781579at2; -.
DR Proteomes; UP000008645; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001267; Thymidine_kinase.
DR PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR Pfam; PF00265; TK; 1.
DR PIRSF; PIRSF035805; TK_cell; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|RuleBase:RU000544};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000544};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
FT ACT_SITE 78
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR035805-1"
SQ SEQUENCE 193 AA; 21742 MW; B284AD09C6B9EC0E CRC64;
MKSGKSKELF SIIDRLNYQK INYKIFKPKL DSRNSNTISS RYFSQSNLAI IINELNPSEI
LDFIPETLSN PLTALIDEAH FFSHELINVV KLMLFKGVNV VISGLDCDAN MNPFGPMGDL
MALANRIKKL NSVCEVCYST ANWSALKDSS QTFERENILV GNDQYVVLCL SCYEKHTGIY
KKLLAEPTTS NNS
//
