ID F0V399_MYCS3 Unreviewed; 614 AA.
AC F0V399;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=hsdM {ECO:0000313|EMBL:CBZ40321.1};
GN ORFNames=MSUIS_02280 {ECO:0000313|EMBL:CBZ40321.1};
OS Mycoplasma suis (strain KI_3806).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=708248 {ECO:0000313|EMBL:CBZ40321.1, ECO:0000313|Proteomes:UP000008645};
RN [1] {ECO:0000313|EMBL:CBZ40321.1, ECO:0000313|Proteomes:UP000008645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KI_3806 {ECO:0000313|Proteomes:UP000008645};
RX PubMed=21398558; DOI=10.1128/JB.00187-11;
RA Oehlerking J., Kube M., Felder K.M., Matter D., Wittenbrink M.M.,
RA Schwarzenbach S., Kramer M.M., Hoelzle K., Hoelzle L.E.;
RT "Complete genome sequence of the hemotrophic Mycoplasma suis strain
RT KI3806.";
RL J. Bacteriol. 193:2369-2370(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FQ790233; CBZ40321.1; -; Genomic_DNA.
DR RefSeq; WP_013608931.1; NC_015153.1.
DR AlphaFoldDB; F0V399; -.
DR REBASE; 34138; M.Msu3806ORF2280P.
DR KEGG; msk:MSUIS_02280; -.
DR HOGENOM; CLU_013049_4_1_14; -.
DR OMA; NSADWAW; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000008645; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:CBZ40321.1};
KW Transferase {ECO:0000313|EMBL:CBZ40321.1}.
FT DOMAIN 4..150
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 159..423
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 614 AA; 71438 MW; 552C416D97E42A43 CRC64;
MSDLAKSLWN FCNELRVYFH LKQSEYYKPA LGALFLKYMD VNYQKTLKIL EKEMPIIEGV
RVSPKKYDFE KKGVIMLPEE AQFSKIISLP EDVTLAKIKN IDGEEMSSLG EVLDNAMKLI
ERESELFEGA LFKEYKKIRD NTLRDLLKVF DREDVSDNSD KLGEVYEYFL GHFSLEEKGD
EGVFFTPKSL VNMIVNILQP KGGKALDPFC GSGGMFVGIK KYMERETDST CNQDFVFRGY
ELLPANVNIC NMNLFMHNIQ INSVIKQCNT FENDLLDLEG KCDYVLSNPP FCVKGVNIER
AKRAGRIPFA LPRGNNESFT NADYLCIQYF YSYLNDRGKA GFVMGKNSLA STGDKEIRKQ
IIETKHVDII IGVADKFFQS GFTGEVCLWF FNKQKIEEQR DKILFIDASN YFSQVKDNPK
QNTWSYWQSK NLIAVVWLYR GQVEKYQKLL EEYREALDKY AKEFNVQIPE SGNYLDAFKG
VGEKLIVEGE EELSKADKKD KNRMKEELDK KWERFEEALS VVKEYDWIRS KFKKGIYRDV
PGLCKAADIK EVMEMDYCLG PRVYVGFEET EEDREDRPAY IKRMKDMHKE LVELEKESQE
LTLQITENLS LWGE
//