ID F0VAK2_NEOCL Unreviewed; 1014 AA.
AC F0VAK2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
GN ORFNames=NCLIV_011580 {ECO:0000313|EMBL:CBZ50691.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ50691.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX51/DBP6
CC subfamily. {ECO:0000256|ARBA:ARBA00038200}.
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DR EMBL; FR823384; CBZ50691.1; -; Genomic_DNA.
DR RefSeq; XP_003880724.1; XM_003880675.1.
DR AlphaFoldDB; F0VAK2; -.
DR GeneID; 13441720; -.
DR VEuPathDB; ToxoDB:NCLIV_011580; -.
DR eggNOG; KOG0338; Eukaryota.
DR eggNOG; KOG0350; Eukaryota.
DR InParanoid; F0VAK2; -.
DR OrthoDB; 214799at2759; -.
DR Proteomes; UP000007494; Chromosome IV.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR PANTHER; PTHR24031:SF68; ATP-DEPENDENT RNA HELICASE DDX51; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU365068};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365068};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 332..699
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 856..1014
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..852
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 111117 MW; B11834B5E41DC9D5 CRC64;
MASEIAPADR GGEEENAQTG KRKKTRDSEY RKLRQEARRL AREGGEKAVE GGACKSKHER
EKTHGTERAA ASGTKGDHVG EARTEKRDDE ANGAREGEER KRKRERGREA EKEGEKREEP
VEGDDGDAGT RLGRKRKRRR RRKNLTEDED TLAHEENGDE AEDEKADRER QEALPNEEGK
RHRKRHMKRK GTRNTEEQSR DEEGQDGEDA NGDSEETDAA QKDSKETPDS QDPSSPSSAS
SSSASSSASS SSSSSSSSPS CAGKERTPRP EFTSRYCVVT QHSAGEEEDE KQAQSLRALH
PCVVDALRRR NIQSLFPVQR TVVHFLTRCI DRPYDAQNCD LCVSAPTGEG KTFCYVLPIV
SFLLGSVVRT TRCVVLVPTR ELAMQVAEEF RRFRHFHPSP FVSRPGSCRT SSSSVRHADA
EENERSDAAD EHAGKRGRKK PESDTGLDGV NTTPLDSTGI CDSKTTLGNQ VVFCRDISVV
CLVGELPVHR NKRGNGSAGG SNSSGTRFAS PLNSDFLASF LGSSHAPEAT SGVSIAGSAS
PDSAAPPDVV VCTPGKFSEM VWNATRRNGG AFSFDAVRGE DGLSLQDEDA LQAGDMRLSL
DDVQWLVIDE ADRLVRQPHH DWMKAVEALQ RLRFEACRTR GRSFASRSPG KVAIPCVSAF
ASPFVASASL PLQKLTFSAT MTKNPKSLAL LNLTRPFFVL STPSGHYSMP QSLAQRYVVC
DSEDKPLCLL LLLLRLARHL ANGGSELGRN RAAVQAASND SNASGDEAKG QEAGGSEDEE
EEKEEKAEEE NAEEEKAEEE NAEEENAEEE NEEEEKAEEG EEKEESDDGE EGGEEAEGGE
SREGEGECGE EPEEGGVSEK RKKMKVLVFC SSRDATHRLA RLLQLYFEHA DSSQIRPTSI
SRFAAFSSSE GQSVPAPSRP DAANGAWRPG DACKEEEEEV ERPLCLRVRE LSSNLSQRDR
MKLINGFKNG TVEVLVCSDL ASRGLDVEGV DAVFHYDAPQ HVQAYVHRSG RSAR
//
