ID F0VFQ4_NEOCL Unreviewed; 3502 AA.
AC F0VFQ4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Phosphofructokinase domain-containing protein {ECO:0000259|Pfam:PF00365};
GN ORFNames=NCLIV_023360 {ECO:0000313|EMBL:CBZ52548.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52548.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
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DR EMBL; FR823388; CBZ52548.1; -; Genomic_DNA.
DR RefSeq; XP_003882580.1; XM_003882531.1.
DR GeneID; 13444707; -.
DR VEuPathDB; ToxoDB:NCLIV_023360; -.
DR eggNOG; KOG2440; Eukaryota.
DR InParanoid; F0VFQ4; -.
DR OrthoDB; 205263at2759; -.
DR UniPathway; UPA00109; UER00182.
DR Proteomes; UP000007494; Chromosome VIIa.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.450; -; 3.
DR Gene3D; 3.40.50.460; Phosphofructokinase domain; 3.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR InterPro; IPR035966; PKF_sf.
DR PANTHER; PTHR43650:SF30; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE-RELATED; 1.
DR PANTHER; PTHR43650; PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE; 1.
DR Pfam; PF00365; PFK; 2.
DR SUPFAM; SSF53784; Phosphofructokinase; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 865..1106
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
FT DOMAIN 2671..2871
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1441..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1775..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2090..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2205..2241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2273..2420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2512..2646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3084..3103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3108..3147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3359..3472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1793..1817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1865..1897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2361..2375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2381..2415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2567..2584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2593..2631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3359..3388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3411..3428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3502 AA; 372751 MW; 882B043BF1E9F7F1 CRC64;
MLMQPSKSLS PLEAERLQDP PQLPRCFAVP PSRPSAGPPH RGASPTRGAS HPDSFSMSPA
LHPASPFVEI AAEFLHPRHA HGTCRAPPLR LASASVLPYS PFVVEEVHLD VEVLGERQSL
GDKEGPAGGT RHAEDAESNR PARDAETSPF SGTKDGEDEL RNGPLDEDEG AHKRKPPVRE
ERPQREETET PRASSPPCEG ERPRVEAAEL ARSFTPGDAQ TAAADVPQVP RSALPSSLSS
PETDTGSESR CSGAEKPSQG PRALAGPSQG RDSPRAAQSP SGAEPLSSRF VAAPEKQGKS
HGQPRPRQET EKGAQVAAKL LDFDPQILHH FPMLANANTR IYQFVQRRYI RKIDGSTSAS
RVSLGESGGW SLPDTQPQPA RGGTAQRRSG MARCIPNAIS LPNLAHAATV LAAMGLEQLS
GPPEPVRQST ADRGDSGNSG EEVGARTMWA QRGVPPSSPS HGDRHGLRRS TTGNRGGSSP
HPGSKVRDTA DENEVRLRSF PGGGNARADA TSDTDATNKG LSPHALAESS SSSSRLSTSD
AAARDAGVPV RSSGGRTGRG ETSSSGRARG REDRACLSAV CGRDRLRHID GAEREDHVPF
PSAAGLRQGL EADEESQRNS PKDKAEAQAD AVGATPFAMA SERPSYGKEE PSPPSASASF
FPQVPPARTE KKLLPPLRLG VVVGGLAPSS GVHNVIVGLS HFLRDFTRAS APDCVCQRGR
RINDGPGDEA GASQSAHFAP SRSNTPFPQT PTIRQSISEP SNLGVRGTGE EGTRKATARE
GMRDEAEARE ADDARPAGVG SPPAPLHDAG RFPTYHATSC ASTFASSGRF SAQGEEAKRV
RDEATGRTPR GEGEPDGLSA CSCSKLIGFL DGALGLAKDD FIELTQETVA SYLNMGGCEL
LGYRAFKSLT DFSISRIQQV CEKHGLHGLV IVGGAEDLQA ATQLAHRFLQ EGLRTRVVAV
PHSARGELHC EEFLPITLGF DSARSMLSEF CGNIALDSSS SKKYYHFVRC SSSNLTLECA
LQTRPTMCLT GLECDIEGWT LERIVEAICD VIVKRRKLLG KRSGTILLSE ELVENLPEAG
RADSASSAAP AWAVQPPTEA SLCALLPARL ARAFRLLPAY ARRSLMLQHD CRGRPLLPAI
EAEALLAQRV EKELRKRKTA GDARCVETFT YRLHYLGQEG RCPLPTRFDC SLGYALGTVA
GAIVSFGLTG YMACVRNVHL PLDRWEACAL PLVCLLKPSP RPPSPASCGP GASSVHPVRG
EDRERGTDWK KRQANPADAE ASGGSTPDAG NSSRQATAQR DEEGRAPEGD LHTSPQGHAQ
PREVYGHAFR SRAGDPAGLA RGTHQPLAVP TIPPYRLAAD SNLFRCYKRV KNSWKVYCLY
RSPGPVSFAP TPRLTLTLCP ACHRYMSFCI CAPPCHSAFR PSPAPLSPAL GDSSVHAAEA
QWQSAARGSS SSASGRGEAS GGAKRGLRAV DGADGDGGAE TLRRKRQELK ATEVHDGSIP
LMLVAQFCSP LETLLRVQPL KLKRSEFTAL FASPETGDAS PVTDASRGLL QIAADPCLSR
NRNSEVPTAS CDLPRDAGGA LPQAPAGEEE RPETRTAGDS ASELGKLSEG GQAGRWPHSG
DREGEMMRKA GAAPSDEGTS DDALLGGEAD WIEDAGSDSE AEDAEERVFP LEPPTLFLNC
RRRCQLSYFQ ICRLDYKPKL PAVFFKPFTL ACMDITAVIS SNPVLLQRIF PLTHNLRAID
VVPMQQLLDA DPWTPAPLPP SSSLLRFWRS PAPAVDGRSS PPALPPPCLP YHLKRGAKRE
STRAQDARGR EQSLDSREGG ARGGGTPCAD PSDAQALGAP ASTARVLSGG AEAAEAGQGC
GDTPAERARE TKERQRGEGG ERGDVEKEGE ERRVREVMNY ACPPGHPDDG KRVYRGETKP
RGSEGRERPP THSAAYEHPA ISRPVSPSPG GMAEALRSAA TTPSRRGGTY EGPGEGLRRG
EGEKKLAPPP QFVGVHRGGL ALRADANLGE ALQFDAHETA NSAAPFFAPS PLDPSPASPS
YASLPHVSLM AEKPRRVSPY PAAFPSAAFV APVAAAPPPL SETLAGLEGT PRKHAQAGEL
APPEPAAVGP SGGWAPGSPA PHVGGSEGIA TLFARPTAGT SDTQRTGGPP AMARIISPSL
VAVSAAEAFG RPAQTAFDTP RSGRGRVEAA ARGEGAEAIG QGVCADARGA NRDTTARGDG
RPQPGSWKVE GGPNRDSGTR HLRLHPLGIV RVASAPQREF PKVEDEDTFQ PSHFVASHST
GHPPLGLRPG PHSGRNSREG SLVAPGVGAR SPPDRSPVAP DGAQRPQSRA SLGPSLLSSD
RALGPRETHA PGGPAGADNV RSRSDPSQTA SALASPEPSR RLLKPPDRGR GADTSPGAER
RVGDSAGDRP TRRAVEGEGG TTALASVRVQ SSAFVACLLR GDEDQREGRS SASSATASGV
VRRNTLIDIR SSASPVVMLR YESGRAESLR LERGGSGRTR FSFDCCEARR APTEERWRSL
SPSHGEGPPA GDASAVPPLT RDEGAARASL SRAGLSTKGK RRVSPASLYF SSPSFSSSSL
GASAQMRGGE EGKLEAANQE GLREGEGGSE REQAEMRDGR SEGEEGPPPS RGVKREPQLT
AKANEGHIEP KLCLSRKSSR VNLVESQEPL RIAVCFFGRQ APGGLNAVMG VLEYLENLAP
KGVCIGILGG ILGLVHGWYT IVDKQSFSLF RNQGGLDLLC RTTEHFSNEF ELQQCIKTIK
ALRLDGLVVL GGTSAVSDAA ILTEYLLDAD TQTCVVGVPM TVDNGMPFIE ACLGHDTVCR
VFNSIIGSLM RESRSSKCWY FIRVSGKCLS HLAAECALDT HPNLVLINEE IEQKRMGAMA
LTNLISDIVE TRAGLGLHYG TVLLPDSLLA HLPEMHMLIN EVDACFESGF YAQTEEGLEL
LRARLTPWSA ALFSSLPKGI QWQLAFNKDQ TYRVDLTAID TEVLLKRLVE RELARRKSIG
AFRKGQFLCK THFLAYQGRS AAPTNFDADL GFSYGYTAAV LVDGGCTGYM AQISNLVRDP
SEWSVSAVPF TCLVDVQPVK PSVTHPCDKS SHVRQPPRHG YHVWSSRATN HAPHSSGHVP
GRPVPSAASH TSEDSKRERD APPRAASSSA GSAVVLMFRV EVPLQKLSLQ GAMFRTLALS
RAEWALGDCF SSPGPVQYEG AASRVRLNSL RLPSTDPTVK LKKISQLCSQ VKSLCSVMAT
PPVLKTAESS LYSLVEVLST LSRSERNQDL QFYDISHVLA QRFTTKAWLS AADSLPLSSL
PSAFSSLPEP GLAEPQWGAG GPGNSCFLSP SYAGRGPKPW ARGDFASSPL PAQFRLCETD
ERQTEAGRER EPGNEARRTR DSDPEKNGDI TGNRSGSLVA FQALTARPYR TGRGGRREWG
DGESDTMPRG NEEAGQAFAQ DATEAGGGDG IGTERSGPRE EEIETLWSGE GHAATKRLPS
FSLVCLNKAS SNYAVQHFQE RR
//
