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Database: UniProt
Entry: F0VQD4_NEOCL
LinkDB: F0VQD4_NEOCL
Original site: F0VQD4_NEOCL 
ID   F0VQD4_NEOCL            Unreviewed;       892 AA.
AC   F0VQD4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00012917};
DE            EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
GN   ORFNames=NCLIV_063570 {ECO:0000313|EMBL:CBZ55931.1};
OS   Neospora caninum (strain Liverpool).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX   NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ55931.1, ECO:0000313|Proteomes:UP000007494};
RN   [1] {ECO:0000313|Proteomes:UP000007494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX   PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA   Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA   Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA   Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA   Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA   Wastling J.M.;
RT   "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT   Neospora caninum: Coccidia differing in host range and transmission
RT   strategy.";
RL   PLoS Pathog. 8:e1002567-e1002567(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC         terminus of a polypeptide.; EC=3.4.19.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000721};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; FR823393; CBZ55931.1; -; Genomic_DNA.
DR   RefSeq; XP_003885957.1; XM_003885908.1.
DR   AlphaFoldDB; F0VQD4; -.
DR   GeneID; 13445154; -.
DR   VEuPathDB; ToxoDB:NCLIV_063570; -.
DR   eggNOG; KOG2100; Eukaryota.
DR   InParanoid; F0VQD4; -.
DR   OrthoDB; 2877590at2759; -.
DR   Proteomes; UP000007494; Chromosome XII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR045550; AARE_N.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR   PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR   Pfam; PF19283; APEH_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT   DOMAIN          168..291
FT                   /note="Acylamino-acid-releasing enzyme N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19283"
FT   DOMAIN          661..873
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          183..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  96960 MW;  D7A507A59E85F8B6 CRC64;
     MHCTMGGSGC PQPAAGDQTK RLREAFSVCS ESVIQCLSAR IAATKSSDPS QDAIVVLGQQ
     KVLNERRVVG MTARVPNCDL LTAWPLGLPS ALTVLSPSAH FFASVVEATP PNAKKKPRPS
     FPQASAADYR IELFGRGPVH TGPVVTVSAP RDTKPWNSSV GGGVFCPERE ELFVYVAEAS
     KRDDNDASSG STSDGTGETS DGDSLDTYEF KTHWGEQLVG HRRGRLVLTD FKRRTAQLLK
     PPKKETACGQ PRFLSDGSGV VCSNWELDPY CLGLIYCMNR ASKVLLAQLP SSTSEEGKAG
     EKADEETKES TVECEWIQIS GDEDFAAWSP TVLHTRDGSD PNTQRIAFLC LEKDKVCPAS
     VCARFPLSTR IPAGLEGGEA GKTDRVFHLS CEEPSVRRRM ALQRTSRVPS LLAFQPETLP
     HMCAPRIKAV TLRRKNACSS WEVVERQTLA QAVSVPPQSE SLFSRQSVPY TGIYTDRLGP
     WVHNDFLFLN TFVGARRTVV VVDAHGGGCV GELCLEEEAL RAKPCAASKV EASCPPGSIL
     LHDVTSDWLL LESSSARHIP RLMLAKLLLS PSGAQSPQSG RGFHIRVAGS VSLGGPSDPQ
     RLLPWSPFAR LTTHLERLEV RYLSDNRHIL LRWKESPRRD GKRALAVVLH GGPHSVWANI
     FSAEAVYLTF LGFDVLAVNY RGSLGFGQAE LLSLLGNVGR QDVDDVKQAV TDFIDSDPEA
     YSPARAVVVG GSHGGFLTCH LIGQFPDMFA AASTRNPVTN LASMVVESDI PDWCAAEALR
     ERLNPSFVLS ETDVVALYKA SPVAYARHVK TPLLLGIGGA DLRVPACQGI AFHKMLLGQG
     SPTRLLFYPE EDHRIDRPSC SEDYWVNTAL WFAGYTGTLE ALKEDVLPAA PH
//
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