ID F0VRD7_NEOCL Unreviewed; 484 AA.
AC F0VRD7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Cysteine synthase, related {ECO:0000313|EMBL:CBZ56285.1};
DE EC=2.5.1.47 {ECO:0000313|EMBL:CBZ56285.1};
GN ORFNames=NCLIV_067100 {ECO:0000313|EMBL:CBZ56285.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ56285.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR823393; CBZ56285.1; -; Genomic_DNA.
DR RefSeq; XP_003886310.1; XM_003886261.1.
DR AlphaFoldDB; F0VRD7; -.
DR GeneID; 13445508; -.
DR VEuPathDB; ToxoDB:NCLIV_067100; -.
DR eggNOG; KOG1481; Eukaryota.
DR InParanoid; F0VRD7; -.
DR OrthoDB; 852805at2759; -.
DR Proteomes; UP000007494; Chromosome XII.
DR GO; GO:0004124; F:cysteine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR CDD; cd01561; CBS_like; 1.
DR Gene3D; 3.40.50.1100; -; 4.
DR InterPro; IPR001216; P-phosphate_BS.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR Pfam; PF00291; PALP; 2.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS00901; CYS_SYNTHASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transferase {ECO:0000313|EMBL:CBZ56285.1}.
FT DOMAIN 148..202
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT DOMAIN 214..411
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT REGION 71..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 52831 MW; 147B7F0DF4972B15 CRC64;
MPGWGFHNHP FHRLSRAERE FGSLPKRGLL PSSGTAFAKP LAPTPGSLNS RFGPGTDLLF
FSDKSTLTSS TRELSFAQPQ PGKQTTDGEE SDRNVSEQLR QAQESTMSYE HNALSSPPGK
PDFSRCAPAA GKRQERNSAL RVCENFLDAV GMTPLIYLRR ASLETHCDIF AKCEFLNPGG
SVKDRPAKYI LQQAEKEGET ATQSTETQCD TQGEDMLKVC GALVVEVPFH KVWHPDHFVA
FSGRLASVLN ACWGNQFDNL ANQLSHYETT GPEIWDQMDG RIDGFVSAAG TGGTVSGVSL
YLRSQHPGIQ IGLADIPGSA LYRYYTEGVL RAEGSSVVEN IGQGRITGQL QGFRPDVAFE
IPDAESLAWT HSLLEDEGLA VGLSSGVNVA AAIRLAKRLG PGHRIVTLLC DSGTRYAKKQ
WNISFLKEEG LPYPRMLADQ SREMSGIMEA IHSAYAPQHV VEKIEKEHEN DISAPGSKLR
SVSL
//
