ID F0XK23_GROCL Unreviewed; 2210 AA.
AC F0XK23;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:EFX01892.1};
GN ORFNames=CMQ_4963 {ECO:0000313|EMBL:EFX01892.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Grosmannia.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX01892.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
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DR EMBL; GL629787; EFX01892.1; -; Genomic_DNA.
DR RefSeq; XP_014171374.1; XM_014315899.1.
DR STRING; 655863.F0XK23; -.
DR GeneID; 25978232; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR InParanoid; F0XK23; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 13..376
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2210 AA; 241438 MW; 54A2489702F105FF CRC64;
MDVQEAAPNN GTSNAIAVVG MACRFPGAAT DIESFWEMLR NGKDAWSEIP EDRFNTKGWY
HPDPNRPGSF HIRGAHFLKE DIAAFDAPFF SISTAEAISM DPQQRILLEV VYEALDSDYE
QPCMRDPDTT PPYAATGNGV AILANRISHV FDFSGTSQTI DTGCSASLIA VHQACKSLLG
GESSLAIAAG VGLIFSPNTL VPMANLNILS PDGRCFTFDE RANGYGRGEG VGVVILKRLE
DAIAANDTIR AIIRATASNQ DGHTQGDIKE AQAVSEVFCQ QRTSDRPLII GSVKPNIGHL
EGSAGVAGII KGILVAERGY IPKHLNFTSP NPNIDFNNMK LQIASQLSPW PVDGLRRVSV
NSFGFGGTNA HVVLDDVPHF LAENDIAGGQ HNTFIYPSDK FPFSLWDELH RDKDTSRIDE
PQIAQPATTA IQVALVDLLI ASGIQPAAVV GHSSGEIAAA YALGAIHRED AWKIAYYRGQ
CVRNISTLAP DVHGRMLAAE LSEDDARRMV SDAGTQSVCI ACINGPASAT LSGDAEEISH
LYTCFQKKGI RTVMVNVDVA YHSPHMHIVE SIYLNAIKDV TPLQQKSNGV FFSSVYGRRI
LASDLGAEYW VKNMVLPVQF FKAVTEVMSQ MSPAVFLEVS PHRVWKSTLR QIHSSATASG
TSPVYLSLLS RESDACDTAL DALGGLWAQG LSFKLEWASS SYGEKPRHLA DTPSYPWDHS
RRYWHESHLS KANRFRSHGR EDIIGAPLEN STPQAPSWRG FFRVQENPWL EDHVIQKSIF
YPAGGMVAMA IEAAKQLSES SRTLKGFEVK EISIIKPMLI PRSPQGLENM FSARLLDKDD
ALSSKNLTCY EFSILSKPED SLWIVHAKGR VSIVYGEECP DPDDYIDPGQ TTKVQRQAFY
RAREACDIEH SPRQFYEDLD VIGMTYGPQF RNLTEIRTDN TAAYTVIEIP DTKACMPFQF
EFDHVIHPTT LDTMIQTVLV LSDGVGEAML PCSIGRIYVS ASLPKGAGSQ FRGYTTAHKT
HMHTARADIS MFDYQLCAPV VTIENLMLKS VPSSGNDGFL PSHRNLCSEI VWKMDIGANC
SLGIDLPESF QDMIDAASHK NPALSILCHV HPLYESVEAP PSFAKQHVAA SYFSGLIFDV
LTVGHETPRF SQLVISGSEL LWRQLCESKR SYPGVERVHS SEMPSANSQF DVVVVSVGVA
GPRDIDSQLF RCVAPDGWII VVPEETGIFS TEQRTELANA VHAAGFQGSK AQNDTFRFFA
AQKNSTTASQ TTSENTILLV LPDQMSELTK ALRDTIRPII KNSLSLEILE VPFSTISSLS
NEELAFSCMC LVELDASTIF CMREDEYESI RRLLMVTKGL LWLTRGAQLG AKDPSRSPFL
GLARAIRSED AKKNIISLDI DVQPAENRIH NMEQLAEKTV LLLKRACSDL PPEPFVEDVE
FVFSEGHLMI PRLMPLPTLN RLIEHGPTMP QSVARIPLTL KDKALKLDNT SVEKPSGLLF
VEDQEGLHRP LHPDEVRIAV VGTNLLPEDI ALASLGAPNA KVGTDAFGHV VEVGINVKDV
WPYCRVVARM RDTIKTHVIA HKSRVRRILH QGEWPGSCPT AFATALYALR TRRRSLEGEV
VLVYGASSAY GQAAIWIALA LGNKVLVACK SSMERKLMLE SFKLPASHVI DAQCSDVEFE
LRILSATFNR GVDVVFDPTS KFIEQAFCCA SEGGCVIRVA WAGCDGSAVR LPLKNVSLET
VDLGLLEARN PLEVERLFFE VDQILQLAPK LGAINGTLEY RMSQVQDALK AATADPFAGS
YVVTTHSDSI HPNTVNIPVP LTQTPRLSQS STYLLIGGLG GLGRAIAEHL VTNGARCIAF
FSRSGGSAPP AQAFIAKLNA KGVYARAFAV DICNEAQLGT AIRELYGSMP PIQGAIQCAA
VVTDAAFPNM DYGCWKQCFG PKTIGSYNLH QLLPRAMDFF VFLSSLSGII GNRGQANYAA
GNSFQDALAR HRSSQGMHSV SLDLGLVLGA GMVAEDESLL DAMRARGFLG TRLQDVLFIL
DRAMARPGTE NIDIPPQIVT SVGTGGLTIQ NQPSDPFWTR AALFRYLNQV DAPPRGFNKI
TGGSSHSGGS ENLRTAIQRT ASMEDAAYLI CTALIASLAR RKSMVPSDFD PLQSLDSYGI
DSLDSLFILG WISRETGVTM QTVDGLTITQ LSQAVAQRSF EALEQDAVRG
//