ID F0XKQ7_GROCL Unreviewed; 1100 AA.
AC F0XKQ7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=CMQ_8096 {ECO:0000313|EMBL:EFX01630.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX01630.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
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DR EMBL; GL629788; EFX01630.1; -; Genomic_DNA.
DR RefSeq; XP_014171112.1; XM_014315637.1.
DR AlphaFoldDB; F0XKQ7; -.
DR STRING; 655863.F0XKQ7; -.
DR GeneID; 25981713; -.
DR eggNOG; KOG1005; Eukaryota.
DR HOGENOM; CLU_001996_0_1_1; -.
DR InParanoid; F0XKQ7; -.
DR OrthoDB; 55913at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR Pfam; PF21399; TERT_C; 1.
DR PRINTS; PR01365; TELOMERASERT.
DR SMART; SM00975; Telomerase_RBD; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 581..928
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1100 AA; 124623 MW; 898406092588EB8A CRC64;
MVDQADMSAL IRRKRKRADA DDSRNIGEAP PSRTKQPRRE ASSEQHPAAH RQLDPVVKHA
LLTRCFPQVL TLRAYLLSRL PASSRIRRKK LREVGLAADP SPVEQRLRRL LDNALVACSH
HDGSGQGDKP LDSLPSLQDD RQQQRLAYIE HKRAEESHVI ISNAQEGVFS PQSEPLCNLE
PLTKFQATEQ TARDTRDEKS LSDISFVRNR MFYAKPSMAQ SGAVHFGLKH IHVLNRFSYR
SCPTKKVGLQ ELAAANNHGT VHMMMYMFPR QFGLHNVFTS VVDRATTAQR FQDYTLREAE
ISAKFGKIGW KDRSASVRIP KRLRGMAVHL VERLRKLHNR CSYYELLQHY CPDIAYQETR
HEVTSAEPGS HKEEAHTLVS LGHPNQESAS KDVATTGQDP APQRQQCVPY SSKSGPELKS
TTPLVELATP LQRVSTFCQA VILNVVPNDF WGNGEAQAKN RQAVLKKVDL FLRLRRFETL
NLHDLMQGIK ISDILWLAPP GLRKGKISQT DVQKRRQIFA EFLYYLFDSF LIPLVRSNFY
VTESSSHRNK LFFFRHDVWR RITEPALVGL KARMFEDIKH GEALQILGSR DLGYGQIRLL
PKQATVRPIM NLRRRTAVKG GTRLGSSANT ILAPVQAMLK FEILMFSLLK KQHPERLGSG
MFSVGTLFKK LKEFKKRMAS ESQHTFYLAK VDVKSAFDTM PQEAVVELVH KLSSHRAYYM
DKHVEMAAPE NRGLGGVFNA AVKGDFVPMR RWKTIASAST DASGFHDVVE SSLATYQRNA
IFADTAYRKP RDSASLVGLA ASHILQNLVK IGKKFYRQKT GIPQGSVLSA LLCNCFYAEL
EAEELGFLDA DGSKGCLLLR LIDDFLLITT DQSKAARFVE VMHRGLPQYG VAVSSDKSLV
NFDLQGPDGK SVSRVANGAW FPYCGLVVNC LTLDIAKDWE TKKQEHARSP GHNFKRKIFN
GFKVLSHVMF FDTAHNSLRT TLCNAHKVFS DTAVKVWAYT RCLPRDKRPS TRLVISTIEE
LSELAYTVLN GRARRMPEYQ FSVFKPQLRW LLLHAFSGVL GKKQAGYSDV LTWIRSEMHY
LRSQQDLRLP KIFIETSVQA
//